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Chloroquine diphosphate

Cat. No. M2510
Chloroquine diphosphate Structure

Chloroquine Phosphate

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
50mg USD 27  USD30 In stock
100mg USD 45  USD50 In stock
200mg USD 72  USD80 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent.

Product Citations
Customer Product Validations & Biological Datas
Source International Journal of Neurosci (2020 Mar) Figure 7. chloroquine (Abmole Bioscience Inc., Houston, TX, USA)
Method Apoptosis detection
Cell Lines BM-MNCs
Concentrations 0 μM, 2.0 μM, 4.0 μM, 8.0 μM or 16.0 μM
Incubation Time 48 h
Results The cell viabilities (means ± SD) of the five 3-MA-treated groups was 100%, 73.13 ± 3.02%, 56.45 ± 2.70%, 34.35 ± 1.65% and 10.14 ± 0.93%, respectively (Figure 7a), while those of the five CHQ-treated groups were 100%, 65.99 ± 3.26%, 48.79 ± 2.51%, 28.04 ± 2.54% and 3.02 ± 0.70%, respectively (Figure 7b).
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 515.86
Formula C18H26ClN3.2H3O4P
CAS Number 50-63-5
Purity >99%
Solubility Water ≥ 30 mg/mL
Storage -20°C, protect from light, sealed
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Keywords: Chloroquine diphosphate, Chloroquine Phosphate supplier, Autophagy, inhibitors

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