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TEMPOL is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects.
| Cell Experiment | |
|---|---|
| Cell lines | HL60 |
| Preparation method | After 96 h exposure of the cells to the drug,assessing the antiproliferative effect of Tempol by the MTT assay . Briefly, 100,000 cells/mL are seeded onto 96-well plates and allowed to grow for 24 h before treatment with different concentrations of Tempol (0.05–1.6 mM). |
| Concentrations | 0.05–1.6 mM |
| Incubation time | 96 h |
| Animal Experiment | |
|---|---|
| Animal models | Male Wistar rats |
| Formulation | Saline |
| Dosages | 30 mg/kg |
| Administration | bolus injection |
| Molecular Weight | 172.24 |
| Formula | C9H18NO2 |
| CAS Number | 2226-96-2 |
| Solubility (25°C) | DMSO 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Neslihan Pinar. Effects of Tempol on Epileptic Activity in Picrotoxin-Induced Epilepsy in Rats
[5] Tlio de Almeida Hermes, et al. Tempol improves redox status in mdx dystrophic diaphragm muscle
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