E-64

Cat. No. M2659

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Size	Price	Availability
5mg	USD 46 USD46	In stock
10mg	USD 72 USD72	In stock
25mg	USD 140 USD140	In stock
50mg	USD 250 USD250	In stock

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E-64 is an irreversible and selective cysteine protease inhibitor with IC50 of 9 nM for papain.

	Source	Arthritis Res Ther (2018). Figure 2. E-64
	Method	Cell viability assay
	Cell Lines	Osteoclasts
	Concentrations	5 μM
	Incubation Time	24 h
	Results	In this study, the resorption of cortical bone in the presence of resorption inhibitors—the cysteine protease inhibitor E-64, the MMP inhibitor GM6001, and the VATPase inhibitor diphyllin—serve mainly as validation of functional resorption on the cortical bone slices and as a reference for the subchondral bone resorption in osteochondral ECM.

Molecular Weight	357.41
Formula	C15H27N5O5
CAS Number	66701-25-5
Solubility (25°C)	DMSO 57 mg/mL Water 5 mg/mL
Storage	Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month

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