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E-64 is an irreversible and selective cysteine protease inhibitor with IC50 of 9 nM for papain.
 |
Source | Arthritis Res Ther (2018). Figure 2. E-64 |
| Method | Cell viability assay | |
| Cell Lines | Osteoclasts | |
| Concentrations | 5 μM | |
| Incubation Time | 24 h | |
| Results | In this study, the resorption of cortical bone in the presence of resorption inhibitors—the cysteine protease inhibitor E-64, the MMP inhibitor GM6001, and the VATPase inhibitor diphyllin—serve mainly as validation of functional resorption on the cortical bone slices and as a reference for the subchondral bone resorption in osteochondral ECM. |
| Molecular Weight | 357.41 |
| Formula | C15H27N5O5 |
| CAS Number | 66701-25-5 |
| Solubility (25°C) | DMSO 57 mg/mL Water 5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Gregory Blass, et al. Chronic cathepsin inhibition by E-64 in Dahl salt-sensitive rats
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