About 30 results found for searched term "E-64" (0.013 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1859 | RepSox (ALK5 Inhibitor II) | ALK |
| RepSox; E-616452; SJN 2511; 616452 | ||
| RepSox (ALK5 Inhibitor II) is a potent and ATP-competitive inhibitor of the TGF-β type I receptor ALK5 (IC50 values are 0.004 and 0.023 μM for ALK5 autophosphorylation and ALK5 binding respectively). | ||
| M2187 | ETP-46464 | ATM/ATR |
| ETP-46464 is a potent inhibitor against mTOR, ATR, DNA-PK, PI 3-Kα and ATM with IC50 of 0.6, 14, 36, 170 and 545 nM, respectively. | ||
| M2280 | Tamoxifen Citrate (ICI 46474) | Estrogen Receptor |
| ICI 46474; Istubal; Nolvadex | ||
| Tamoxifen Citrate is an antagonist of the estrogen receptor by competitive inhibition of estrogen binding. | ||
| M2376 | Aloxistatin | Cathepsin |
| E64d | ||
| Aloxistatin (E64d) is an irreversible and membrane-permeable cysteine protease inhibitor. | ||
| M2381 | AMD3465 hexahydrobromide (AMD3465 ) | CXCR |
| GENZ-644494 hexahydrobromide | ||
| AMD3465 hexahydrobromide（AMD3465 ) is an effective CXCR4 antagonist that inhibits 12G5 mAb in SupT1 cells. The IC50 values of CXCL12AF647 and CXCR4 were 0.75 nM and 18 nM, respectively. AMD 3465 also effectively inhibited X4 HIV replication (IC50, 1-10 nM), but not R5 HIV replication. | ||
| M2659 | E-64 | Autophagy |
| Proteinase inhibitor E 64 | ||
| E-64 is an irreversible and selective cysteine protease inhibitor with IC50 of 9 nM for papain. | ||
| M2690 | Ethoxzolamide | Carbonic Anhydrase |
| Redupresin; L-643786; PNU-4191 | ||
| Ethoxzolamide is an inhibitor of the metalloenzyme carbonic anhydrase, which inhibits hCA I, hCA II, hCA IV, hCA VI and hCA VII with Ki of 25 nM, 8 nM, 93 nM, 43 nM and 0.8 nM, respectively. | ||
| M2823 | Loxistatin Acid | Cathepsin |
| E-64C; NSC 694279; EP 475 | ||
| Loxistatin Acid (E-64C), a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor. | ||
| M3362 | Tolfenamic Acid | COX |
| GEA 6414 | ||
| Tolfenamic Acid is a COX-2 inhibitor, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1. | ||
| M3549 | Orlistat | FAS |
| Tetrahydrolipstatin; Ro-18-0647 | ||
| Orlistat is an irreversible inhibitor of pancreatic and gastric lipases with IC50 of 122 ng/ml for PL from human duodenal juice. | ||
| M3761 | TH-237A | Others |
| meso-GS 164 | ||
| TH-237A is a novel neuroprotective agent, which possess protective properties against β-amyloid (Aβ)-induced neurodegeneration associated with Alzheimer's disease. | ||
| M3780 | XL647 | EGFR/HER2 |
| EXEL-7647, KD-019 | ||
| XL647 is an extremely potent and selective inhibitor of EGFR phosphorylation (IC50 = 0.3 nM). | ||
| M3784 | Genz-644282 | Topoisomerase |
| Genz 644282 is a novel non-camptothecin topoisomerase I inhibitor with an IC50 value of 0.4 nM in human bone marrow CFU-GM assay. | ||
| M3882 | Netupitant | Neurokinin Receptor |
| CHEBI441603, CID6451149, D05152 | ||
| Netupitant is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity with Ki of 0.95 nM. | ||
| M4477 | Costunlide | Apoptosis |
| (+)-Costunolide; Costunolid; Costus lactone; NSC 106404 | ||
| Costunlide | ||
| M5431 | Atosiban Acetate | Vasopressin Receptor |
| RW22164 acetate; RWJ22164 acetate | ||
| Atosiban (RW22164; Tractocile) Acetate is a nonapeptide, desamino-oxytocin analogue, and a competitive vasopressin/oxytocin receptor antagonist (VOTra). Atosiban inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane. | ||
| M5437 | Azimilide | Potassium Channel |
| NE-10064 | ||
| Azimilide(NE-10064) is a class III antiarrhythmic compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes. | ||
| M5648 | Floxuridine | DNA/RNA Synthesis |
| Deoxyfluorouridine; FUDR; NSC 27640 | ||
| Floxuridine (5-fluorouracil 2'-deoxyriboside) is a pyrimidine analogue that is also an antitumor metabolite of oncology. Floxuridine inhibits the Poly(ADP-Ribose) polymerase and induces DNA damage in vitro by activating ATM and ATR checkpoint signaling pathways. Floxuridine is an effective inhibitor of Staphylococcus aureus infection and can induce apoptosis. Floxuridine is resistant to HSV and CMV viruses. | ||
| M6704 | EHT 1864 2HCl | Ras |
| EHT 1864 is a potent inhibitor of Rac family GTPases. EHT 1864 directly binds and impairs the ability of this small GTPase to engage critical downstream effectors required for growth transformation. The Kd values are 40, 50, 60, and 230 nM for Rac1, Rac1b, Rac2 and Rac3, respectively. | ||
| M6804 | IBMX | PDE |
| IMX; Isobutylmethylxanthine; Methylisobutylxanthine; NSC165960; SC2964; 3-isobutyl-1-methylxanthine | ||
| IBMX is a pDE inhibitor (non-selective) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively. | ||
| M7249 | SB 203580 hydrochloride | p38 MAPK |
| Adezmapimod hydrochloride ; RWJ 64809 hydrochloride | ||
| SB 203580 hydrochloride is a selective inhibitor of p38 MAPK; water-soluble. | ||
| M8303 | Azimilide dihydrochloride | AChR/AChE |
| NE-10064 Dihydrochloride | ||
| Azimilide is an investigational class III anti-arrhythmic compound that blocks fast and slow components of the delayed rectifier cardiac potassium channels. | ||
| M8510 | Cariporide | Na+/H+ Exchanger (NHE) |
| HOE-642 | ||
| Cariporide is a selective inhibitor of the Na+/H+ exchanger subtype 1 (NHE-1), also known as the Na+/H+ antiporter. | ||
| M9006 | NSC5844 | CCR |
| RE640 | ||
| NSC5844 (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic properties. | ||
| M9289 | E6446 dihydrochloride | TLR |
| E6446 2HCl; E-6446 hydrochloride | ||
| E6446 dihydrochloride is a potent and orally acitve antagonist of TLR7 and TLR9. E6446 dihydrochloride is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. | ||
| M9475 | Sardomozide dihydrochloride | Others |
| Sardomozide 2HCl; CGP 48664A | ||
| Sardomozide dihydrochloride (also known as SAM486A or CGP48664) is a second-generation polyamine synthesis inhibitor, which inhibits the activity of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC). | ||
| M10427 | OVA Peptide (257-264) TFA | Peptides |
| OVA Peptide (257-264) TFA is a class I (Kb)-restricted peptide epitope of OVA, an octameric peptide from ovalbumin presented by the class I MHC molecule, H-2Kb. | ||
| M10532 | Tazemetostat hydrobromide | Histone Methyltransferase |
| EPZ-6438 hydrobromide; Tazemetostat HBr | ||
| Tazemetostat (EPZ-6438) hydrobromide is a first-in-class potent, selective and orally available EZH2 inhibitor. | ||
| M11279 | GNE-6468 | Others |
| Gne-6468 is a potent and selective RORγ (RORc) reverse agonist with an EC50 value of 2 nM. Gne-6468 inhibited IL-17 in PBMC with EC50 value of 30 nM. | ||
| M11308 | E6446 | TLR |
| E-6446 | ||
| E6446 is an inhibitor of Toll-like receptor (TLR) 7 and 9 signaling in a variety of human and mouse cell types and inhibits DNA-TLR9 interactions in vitro. E6446 is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. | ||
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