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Cat. No. M2690
Ethoxzolamide Structure

Redupresin; L-643786; PNU-4191

Size Price Availability
100mg USD 200  USD200 1-2 Weeks
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Ethoxzolamide is an inhibitor of the metalloenzyme carbonic anhydrase, which inhibits hCA I, hCA II, hCA IV, hCA VI and hCA VII with Ki of 25 nM, 8 nM, 93 nM, 43 nM and 0.8 nM, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 258.32
Formula C9H10N2O3S2
CAS Number 452-35-7
Purity >98%
Solubility DMSO 30 mg/mL
Storage at -20°C

[1] Alejandro Ciocci Pardo, et al. Myocardial and mitochondrial effects of the anhydrase carbonic inhibitor ethoxzolamide in ischemia-reperfusion

[2] Mohammad M Rahman, et al. Antibacterial activity of ethoxzolamide against Helicobacter pylori strains SS1 and 26695

[3] Joyanta K Modak, et al. Anti- Helicobacter pylori activity of ethoxzolamide

[4] Benjamin K Johnson, et al. The Carbonic Anhydrase Inhibitor Ethoxzolamide Inhibits the Mycobacterium tuberculosis PhoPR Regulon and Esx-1 Secretion and Attenuates Virulence

[5] No authors listed. J Am Med Assoc. ETHOXZOLAMIDE

Abmole Inhibitor Catalog 2017

Keywords: Ethoxzolamide, Redupresin; L-643786; PNU-4191 supplier, Carbonic Anhydrase, inhibitors

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