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AMD3465 hexahydrobromide（AMD3465 ) is an effective CXCR4 antagonist that inhibits 12G5 mAb in SupT1 cells. The IC50 values of CXCL12AF647 and CXCR4 were 0.75 nM and 18 nM, respectively. AMD 3465 also effectively inhibited X4 HIV replication (IC50, 1-10 nM), but not R5 HIV replication.
| Molecular Weight | 896.07 |
| Formula | C24H38N6.6HBr |
| CAS Number | 185991-07-5 |
| Solubility (25°C) | Water 95 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[5] Sigrid Hatse, et al. AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor
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