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Reparixin is a noncompetitive allosteric inhibitor of IL-8 (CXCL8) activation of CXCR1 and CXCR2 chemokine receptors with IC50 of 1 and 100 nM, respectively. Reparixin effectively decreased systolic blood pressure and increased the blood flow. Treatment with reparixin significantly counteracts secondary degeneration by reducing oligodendrocyte apoptosis, migration to the injury site of neutrophils and ED-1-positive cells.
Cell Death Dis. 2020 May 29;11(5):405.
The interaction of interleukin-8 and PTEN inactivation promotes the malignant progression of head and neck squamous cell carcinoma via the STAT3 pathway
Reparixin purchased from AbMole
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Source | Cell Death & Disease (2020 May). Figure 3. Reparixin (Abmole Bioscience, US) |
| Method | i.p. | |
| Cell Lines | Six-week-old BALB/c male nude mice | |
| Concentrations | 15 mg/kg | |
| Incubation Time | once a day | |
| Results | Interestingly, we found that using Reparixin alone could also inhibit the migration and invasion ability of HNSCC cells. These results suggested that Reparixin may block both the exogenous IL-8 and autocrine IL-8 of tumor cells. |
| Molecular Weight | 283.39 |
| Formula | C14H21NO3S |
| CAS Number | 266359-83-5 |
| Solubility (25°C) | DMSO ≥ 25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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