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About 30 results found for searched term "CXCR" (0.023 seconds)
| Cat.No. | Name | Information |
|---|---|---|
| M1898 | Plerixafor (AMD3100) | Plerixafor (AMD3100) is a CXCR4 chemokine receptor antagonist. |
| M2041 | WZ 811 | WZ811 is a highly competitive CXCR4 antagonist with oral activity. WZ811 effectively inhibited CXCR4/SDF-1 (also known as CXCL12) -mediated regulation of cAMP level (EC50=1.2 nM) and SDF-1-induced matrix glue invasion (EC50=5.2 nM) in cells. |
| M2161 | SCH527123 | SCH527123 is a novel, selective CXCR2 receptor antagonist with IC50 of 3 nM. |
| M2381 | AMD3465 hexahydrobromide（AMD3465 ) | AMD3465 hexahydrobromide（AMD3465 ) is an effective CXCR4 antagonist that inhibits 12G5 mAb in SupT1 cells. The IC50 values of CXCL12AF647 and CXCR4 were 0.75 nM and 18 nM, respectively. AMD 3465 also effectively inhibited X4 HIV replication (IC50, 1-10 nM), but not R5 HIV replication. |
| M3769 | Plerixafor 8HCl | Plerixafor 8HCl (AMD3100 8HCl) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively. |
| M3887 | SB225002 | SB225002 is a potent and selective non-peptide inhibitor of CXCR2 with IC50 of 22 nM and >150-fold selectivity over CXCR1 and four other 7-TMRs. |
| M4204 | Baohuoside-I | Baohuoside I is a flavonoid obtained from Epimedium Korean. As an inhibitor of CXCR4, Baohuoside I can inhibit the expression of CXCR4 and induce apoptosis, showing antitumor activity. |
| M5160 | Reparixin | Reparixin is a noncompetitive allosteric inhibitor of IL-8 (CXCL8) activation of CXCR1 and CXCR2 chemokine receptors with IC50 of 1 and 100 nM, respectively. |
| M5165 | MSX-122 | MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions (IC50 = 10 nM). |
| M5210 | GSK1325756 (Danirixin) | GSK1325756 (Danirixin) is a non-peptide, high affinity, selective and reversible CXCR2 antagonist, with IC50 of 12.5 nM for CXCL8. |
| M6217 | AMD-070 | AMD-070 is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, and inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs. |
| M6271 | SRT3109 | SRT3109 is a CXCR2 ligand for use in the treatment of chemokine mediated diseases and conditions. |
| M7261 | SB 265610 | SB 265610 is a potent CXCR2 antagonist. |
| M7262 | SB 332235 | SB 332235 is a potent CXCR2 antagonist. |
| M9275 | AZD-5069 | AZD-5069 is a potent CXCR2 chemokine receptor antagonist, and is claimed to be useful in the treatment of inflammatory diseases. |
| M9070 | AMG 487 | AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) with IC50 values of 8nM and 8.2nM for I-IP-10 and I-ITAC, respectively. |
| M9286 | MSX-127 | MSX-127 (NSC-23026) is a CXCR4 receptor modulator. |
| M9288 | MSX-130 | MSX-130 is CXCR4 Antagonist. |
| M9751 | VUF11207 fumarate | VUF11207 fumarate is a CXCR7 agonist and a high-potency CXCR7 ligand (pKi=8.1). |
| M9821 | SX-682 | SX-682 is a potent and selective CXCR1/2 allosteric inhibitor, it may be useful for castration-resistant prostate cancer. |
| M10141 | ATI-2341 TFA | ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4). |
| M10215 | Motixafortide (BL-8040) | Motixafortide (BL-8040, BKT140) is a synthetic cyclic peptide consisting of 14 amino acids and is an antagonist of CXCR4 with an IC50 value of approximately 1 nM.Motixafortide (BL-8040) is an antagonist of CXCR4 with an IC50 value of approximately 1 nM. |
| M10230 | LY2510924 | LY2510924 is a potent and selective CXCR4 antagonist, which blocks SDF-1 binding to CXCR4 with IC50 of 0.079 nM. |
| M11027 | SRT3190 | SRT3190 is an antagonist of CXCR2 that can be used in chemokine-mediated disease studies. |
| M13922 | BX471 hydrochloride | BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist with Ki of 1 nM for human CCR1, and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. |
| M13938 | ALX 40-4C Trifluoroacetate | ALX 40-4C Trifluoroacetate is a small peptide inhibitor of the chemokine receptor CXCR4, inhibits SDF-1 from binding CXCR4 with a Ki of 1 μM, and suppresses the replication of X4 strains of HIV-1; ALX 40-4C Trifluoroacetate also acts as an antagonist of the APJ receptor, with an IC50 of 2.9 μM. |
| M13939 | Mavorixafor trihydrochloride | Mavorixafor trihydrochloride (AMD-070 trihydrochloride) is a potent, selective and orally available CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding, and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC50 of 1 and 9 nM, respectively. |
| M13940 | CXCR2-IN-1 | CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonist with a pIC50 of 9.3. |
| M13941 | CXCR2-IN-2 | CXCR2-IN-2 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist (IC50=5.2 nM/1 nM in β-arrestin assay/CXCR2 Tango assay, respectively). |
| M13942 | IT1t dihydrochloride | IT1t dihydrochloride is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. |
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