Free shipping on all orders over $ 500

CXCR C X C Chemokine Receptor

Inhibitors

Cat.No.  Name Information
M3887 SB225002 SB225002 is a potent and selective non-peptide inhibitor of CXCR2 with IC50 of 22 nM and >150-fold selectivity over CXCR1 and four other 7-TMRs.
M5160 Reparixin Reparixin is a noncompetitive allosteric inhibitor of IL-8 (CXCL8) activation of CXCR1 and CXCR2 chemokine receptors with IC50 of 1 and 100 nM, respectively.
M11027 SRT3190 SRT3190 is an antagonist of CXCR2 that can be used in chemokine-mediated disease studies.
M10230 LY2510924 LY2510924 is a potent and selective CXCR4 antagonist, which blocks SDF-1 binding to CXCR4 with IC50 of 0.079 nM.
M10215 Motixafortide (BL-8040) Motixafortide (BL-8040) is an antagonist of CXCR4 with IC50 value of 1 nM.
M10141 ATI-2341 TFA ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4).
M9821 SX-682 SX-682 is a potent and selective CXCR1/2 allosteric inhibitor, it may be useful for castration-resistant prostate cancer.
M9751 VUF11207 fumarate VUF11207 fumarate is a CXCR7 agonist and a high-potency CXCR7 ligand (pKi=8.1).
M9653 JMS-17-2 JMS-17-2 is a potent and selective CX3CR1 antagonist with IC50 of 0.32 nM.
M9288 MSX-130 MSX-130 is CXCR4 Antagonist.
M9286 MSX-127 MSX-127 (NSC-23026) is a CXCR4 receptor modulator.
M9275 AZD-5069 AZD-5069 is a potent CXCR2 chemokine receptor antagonist, and is claimed to be useful in the treatment of inflammatory diseases.
M9070 AMG 487 AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) with IC50 values of 8nM and 8.2nM for I-IP-10 and I-ITAC, respectively.
M6271 SRT3109 SRT3109 is a CXCR2 ligand for use in the treatment of chemokine mediated diseases and conditions.
M6217 AMD-070 AMD-070 is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, and inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs.
M5210 GSK1325756 GSK1325756 (Danirixin) is a non-peptide, high affinity, selective and reversible CXCR2 antagonist.
M5165 MSX-122 MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions (IC50 = 10 nM).
M5160 Reparixin Reparixin is a noncompetitive allosteric inhibitor of IL-8 (CXCL8) activation of CXCR1 and CXCR2 chemokine receptors with IC50 of 1 and 100 nM, respectively.
M4204 Baohuoside-I Baohuoside I is a flavonoid obtained from Epimedium Korean. As an inhibitor of CXCR4, Baohuoside I can inhibit the expression of CXCR4 and induce apoptosis, showing antitumor activity.
M3887 SB225002 SB225002 is a potent and selective non-peptide inhibitor of CXCR2 with IC50 of 22 nM and >150-fold selectivity over CXCR1 and four other 7-TMRs.
M3769 Plerixafor 8HCl Plerixafor 8HCl (AMD3100 8HCl) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively.
M2381 AMD 3465 hexahydrobromide AMD 3465 HexAhydrobromide genZ-644494 Hexahydrobromide is an effective CXCR4 antagonist that inhibits 12G5 mAb in SupT1 cells. The IC50 values of CXCL12AF647 and CXCR4 were 0.75 nM and 18 nM, respectively. AMD 3465 also effectively inhibited X4 HIV replication (IC50, 1-10 nM), but not R5 HIV replication.



Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.