| Cat.No. | Name | Information |
|---|---|---|
| M3887 | SB225002 | SB225002 is a potent and selective non-peptide inhibitor of CXCR2 with IC50 of 22 nM and >150-fold selectivity over CXCR1 and four other 7-TMRs. |
| M5160 | Reparixin | Reparixin is a noncompetitive allosteric inhibitor of IL-8 (CXCL8) activation of CXCR1 and CXCR2 chemokine receptors with IC50 of 1 and 100 nM, respectively. |
| M1898 | Plerixafor (AMD3100) | Plerixafor (AMD3100) is a CXCR4 chemokine receptor antagonist. |
| M13942 | IT1t dihydrochloride | IT1t dihydrochloride is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. |
| M13940 | CXCR2-IN-1 | CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonist with a pIC50 of 9.3. |
| M13939 | Mavorixafor trihydrochloride | Mavorixafor trihydrochloride (AMD-070 trihydrochloride) is a potent, selective and orally available CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding, and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC50 of 1 and 9 nM, respectively. |
| M13938 | ALX 40-4C Trifluoroacetate | ALX 40-4C Trifluoroacetate is a small peptide inhibitor of the chemokine receptor CXCR4, inhibits SDF-1 from binding CXCR4 with a Ki of 1 μM, and suppresses the replication of X4 strains of HIV-1; ALX 40-4C Trifluoroacetate also acts as an antagonist of the APJ receptor, with an IC50 of 2.9 μM. |
| M10230 | LY2510924 | LY2510924 is a potent and selective CXCR4 antagonist, which blocks SDF-1 binding to CXCR4 with IC50 of 0.079 nM. |
| M10215 | Motixafortide (BL-8040) | Motixafortide (BL-8040, BKT140) is a synthetic cyclic peptide consisting of 14 amino acids and is an antagonist of CXCR4 with an IC50 value of approximately 1 nM.Motixafortide (BL-8040) is an antagonist of CXCR4 with an IC50 value of approximately 1 nM. |
| M10141 | ATI-2341 TFA | ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4). |
| M9821 | SX-682 | SX-682 is an orally bioavailable, potent and selective CXCR1/2 allosteric inhibitor, it may be useful for castration-resistant prostate cancer. |
| M9751 | VUF11207 fumarate | VUF11207 fumarate is a CXCR7 agonist and a high-potency CXCR7 ligand (pKi=8.1). |
| M9653 | JMS-17-2 | JMS-17-2 is a potent and selective CX3CR1 antagonist with IC50 of 0.32 nM. |
| M9288 | MSX-130 | MSX-130 is CXCR4 Antagonist. |
| M9286 | MSX-127 | MSX-127 (NSC-23026) is a CXCR4 receptor modulator. |
| M9275 | AZD-5069 | AZD-5069 is a potent CXCR2 chemokine receptor antagonist, and is claimed to be useful in the treatment of inflammatory diseases. |
| M9070 | AMG 487 | AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) with IC50 values of 8nM and 8.2nM for I-IP-10 and I-ITAC, respectively. |
| M7261 | SB 265610 | SB 265610 is a potent CXCR2 antagonist. |
| M6271 | SRT3109 | SRT3109 is a CXCR2 ligand for use in the treatment of chemokine mediated diseases and conditions. |
| M6217 | Mavorixafor | Mavorixafor (AMD-070) is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, and inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs. |
| M5210 | GSK1325756 | GSK1325756 (Danirixin) is a non-peptide, high affinity, selective and reversible CXCR2 antagonist, with IC50 of 12.5 nM for CXCL8. |
| M5165 | MSX-122 | MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions (IC50 = 10 nM). |
| M4204 | Baohuoside-I | Baohuoside I is a flavonoid obtained from Epimedium Korean. As an inhibitor of CXCR4, Baohuoside I can inhibit the expression of CXCR4 and induce apoptosis, showing antitumor activity. |
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