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UNBS5162

Cat. No. M13947
UNBS5162 Structure
Size Price Availability Quantity
10mg USD 180  USD180 In stock
50mg USD 540  USD540 In stock
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Quality Control & Documentation
Biological Activity

UNBS5162 is a pan-antagonist of CXCL chemokine expression, with anti-tumor activity.

Chemical Information
Molecular Weight 326.35
CAS Number 956590-23-1
Solubility (25°C) DMSO 21.5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hong-Hai Li, et al. UNBS5162 as a novel naphthalimide holds efficacy in human gastric carcinoma cell behaviors mediated by AKT/ERK signaling pathway

[2] Yingyi Ye, et al. UNBS5162 and amonafide inhibits tumor progression in human melanoma by the AKT/mTOR pathway

[3] Qiang Wang, et al. UNBS5162 inhibits SKOV3 ovarian cancer cell proliferation by regulating the PI3K/AKT signalling pathway

[4] Fan Zhang, et al. UNBS5162 inhibits colon cancer growth via suppression of PI3K/Akt signaling pathway

[5] Bing Wang, et al. UNBS5162 inhibits proliferation of human retinoblastoma cells by promoting cell apoptosis

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  Catalog
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Keywords: UNBS5162 supplier, CXCR, inhibitors, activators


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