Free shipping on all orders over $ 500


Cat. No. M13947
UNBS5162 Structure
Size Price Availability Quantity
10mg USD 180  USD180 In stock
50mg USD 540  USD540 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

UNBS5162 is a pan-antagonist of CXCL chemokine expression, with anti-tumor activity.

Chemical Information
Molecular Weight 326.35
CAS Number 956590-23-1
Solubility (25°C) DMSO 21.5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Hong-Hai Li, et al. UNBS5162 as a novel naphthalimide holds efficacy in human gastric carcinoma cell behaviors mediated by AKT/ERK signaling pathway

[2] Yingyi Ye, et al. UNBS5162 and amonafide inhibits tumor progression in human melanoma by the AKT/mTOR pathway

[3] Qiang Wang, et al. UNBS5162 inhibits SKOV3 ovarian cancer cell proliferation by regulating the PI3K/AKT signalling pathway

[4] Fan Zhang, et al. UNBS5162 inhibits colon cancer growth via suppression of PI3K/Akt signaling pathway

[5] Bing Wang, et al. UNBS5162 inhibits proliferation of human retinoblastoma cells by promoting cell apoptosis

Related CXCR Products

ML339 is a selective CXCR6 antagonist with an IC50 of 140 nM. ML339 has no inhibitory effect on CXCR5, CXCR4 and apelin receptor (APJ).


FC131 TFA is a CXCR4 antagonist, inhibits [125I]-SDF-1 binding to CXCR4, with an IC50 of 4.5 nM.


CTCE-0214 is a chemokine CXC receptor 4 (CXCR4) agonist, SDF-1α (stromal cell-derived factor-1α) peptide analog.


TC14012, a serum-stable derivative of T140, is a selective and peptidomimetic CXCR4 antagonist with an IC50 of 19.3 nM.

CXCR4 antagonist 4

CXCR4 antagonist 4 is a potent, orally active CXCR4 antagonist (IC50=24 nM) with diminished CYP 2D6 activity, improved PAMPA permeability, potent inhibition of human immunodeficiency virus entry (IC50=7 nM).

Abmole Inhibitor Catalog

Keywords: UNBS5162 supplier, CXCR, inhibitors, activators

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.