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VUF11207 fumarate

Cat. No. M9751
VUF11207 fumarate Structure
Size Price Availability Quantity
10mg USD 208 In stock
25mg USD 508 In stock
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Quality Control
Biological Activity

VUF11207 fumarate is a CXCR7 agonist and a high-potency CXCR7 ligand (pKi=8.1). VUF11207 fumarate induces recruitment of β-arrestin2 (pEC50=8.8) and subsequent internalization (pEC50=7.9) of CXCR7.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 586.65
Formula C31H39FN2O8
CAS Number 1785665-61-3
Purity >98%
Solubility DMSO ≥ 100 mg/mL
Storage at -20°C
References

Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists
Maikel Wijtmans, et al. Eur J Med Chem. 2012 May;51:184-92. PMID: 22424612.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: VUF11207 fumarate supplier, CXCR, inhibitors

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