VUF11207 fumarate is a CXCR7 agonist and a high-potency CXCR7 ligand (pKi=8.1). VUF11207 fumarate induces recruitment of β-arrestin2 (pEC50=8.8) and subsequent internalization (pEC50=7.9) of CXCR7.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||DMSO ≥ 100 mg/mL|
Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists
Maikel Wijtmans, et al. Eur J Med Chem. 2012 May;51:184-92. PMID: 22424612.
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