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WZ 811

Cat. No. M2041
WZ 811 Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 42.3  USD47 In stock
10mg USD 60.3  USD67 In stock
50mg USD 177.3  USD197 In stock
100mg USD 258.3  USD287 In stock
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Quality Control
Biological Activity

WZ811 is a highly potent competitive antagonist of CXCR4. WZ811 shows subnanomolar potency (EC50 = 0.3 nM) in an affinity binding assay. WZ811 inhibits CXCR4/stromal cell-derived factor-1 (SDF-1)-mediated modulation of cyclic adenosine monophophate (cAMP) levels (EC50 = 1.2 nM). In addition, WZ811 efficiently inhibits SDF-1 induced Matrigel invasion (EC50 = 5.2 nM).

Customer Product Validations & Biological Datas
Source PLoS One (2017). Figure 2. WZ 811
Method Cytotoxicity assay
Cell Lines U87.CD4.CXCR4 cells
Concentrations 100 μM
Incubation Time -
Results 100 μMof CTCE-9908, WZ811 and Me6TREN did not affect the calcium flux evoked by CXCL12 (IC50s >100,000 nM)
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 290.36
Formula C18H18N4
CAS Number 55778-02-4
Purity >99%
Solubility DMSO 10 mg/mL
Storage at -20°C

Dipyrimidine amines: a novel class of chemokine receptor type 4 antagonists with high specificity.
Zhu A, et al. J Med Chem. 2010 Dec 23;53(24):8556-68. PMID: 21105715.

Discovery of small molecule CXCR4 antagonists.
Zhan W, et al. J Med Chem. 2007 Nov 15;50(23):5655-64. PMID: 17958344.

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Keywords: WZ 811 supplier, CXCR, inhibitors

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