CXCR C X C Chemokine Receptor

Cat.No.	Name	Information
M3887	SB225002	SB225002 is a potent and selective non-peptide inhibitor of CXCR2 with IC50 of 22 nM and >150-fold selectivity over CXCR1 and four other 7-TMRs.
M5160	Reparixin	Reparixin is a noncompetitive allosteric inhibitor of IL-8 (CXCL8) activation of CXCR1 and CXCR2 chemokine receptors with IC50 of 1 and 100 nM, respectively.
M1898	Plerixafor (AMD3100)	Plerixafor (AMD3100) is a CXCR4 chemokine receptor antagonist.
M20617	ATI-2341	ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization.
M14694	E6130	E6130 is an orally active and highly selective CX3CR1 modulator, that may be effective for treatment of inflammatory bowel disease.
M13944	Reparixin L-lysine salt	Reparixin L-lysine salt is an allosteric inhibitor of chemokine receptor 1/2 (CXCR1/2) activation.
M13943	NBI-74330	NBI-74330 is a potent antagonist for CXCR3, and exhibits potent inhibition of (¹²⁵I)CXCL10 and (¹²⁵I)CXCL11 specific binding with Ki of 1.5 and 3.2 nM, respectively.
M13941	CXCR2-IN-2	CXCR2-IN-2 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist (IC₅₀=5.2 nM/1 nM in β-arrestin assay/CXCR2 Tango assay, respectively).
M11027	SRT3190	SRT3190 is an antagonist of CXCR2 that can be used in chemokine-mediated disease studies.