ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization.
| Molecular Weight | 2256.82 |
| Formula | C104H178N26O25S2 |
| CAS Number | 1337878-62-2 |
| Solubility (25°C) | DMSO 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related CXCR Products |
|---|
| AMD 070 hydrochloride
AMD 070 hydrochloride is a selective, orally active chemokine receptor (CXCR4) antagonist with an IC50 value of 13 nM. |
| DOTA-CXCR4-L
DOTA-CXCR4-L is a CXCR4 targeting peptide. |
| Pentixafor
Pentixafor is a peptide that targets CXCR4. |
| CXCR4-IN-1
CXCR4-IN-1 is a CXCR4 inhibitor (IC50: 20 nM). |
| CCR7 antagonist 1
CCR7 antagonist 1 is a dual CXCR2 (IC50 of 11.02 μM) and CCR7 (IC50 of 0.43 μM) antagonist. |
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