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ATI-2341

Cat. No. M20617

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ATI-2341 Structure

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Quality Control & Documentation
Biological Activity

ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization.

Chemical Information
Molecular Weight 2256.82
Formula C104H178N26O25S2
CAS Number 1337878-62-2
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Te Jiang, et al. Inflammation. Sigma-1 Receptor Alleviates Airway Inflammation and Airway Remodeling Through AMPK/CXCR4 Signal Pathway

[2] Jess M Planesas, et al. J Mol Graph Model. Studying the binding interactions of allosteric agonists and antagonists of the CXCR4 receptor

[3] Mariusz Z Ratajczak, et al. Expert Opin Biol Ther. The use of chemokine receptor agonists in stem cell mobilization

[4] Jay M Janz, et al. J Am Chem Soc. Direct interaction between an allosteric agonist pepducin and the chemokine receptor CXCR4

[5] Boris Tchernychev, et al. Proc Natl Acad Sci U S A. Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells

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Keywords: ATI-2341 supplier, CXCR, inhibitors, activators

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