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JMS-17-2 is a potent and selective CX3CR1 antagonist with IC50 of 0.32 nM. JMS-17-2 can impairs metastatic seeding and colonization of breast cancer cells.
In vivo, JMS-17-2 (10 mg/kg; i.p.; twice a day for three weeks) causes a dramatic reduction of tumors in both skeleton and visceral organs in SCID mice.
Molecular Weight | 419.95 |
Formula | C25H26ClN3O |
CAS Number | 1380392-05-1 |
Solubility (25°C) | DMSO ≥ 10 mg/mL |
Storage | 2-8°C, protect from light, dry, sealed |
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