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JMS-17-2

Cat. No. M9653
JMS-17-2 Structure
Size Price Availability Quantity
5mg USD 357  USD357 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

JMS-17-2 is a potent and selective CX3CR1 antagonist with IC50 of 0.32 nM. JMS-17-2 can impairs metastatic seeding and colonization of breast cancer cells. 

In vivo, JMS-17-2 (10 mg/kg; i.p.; twice a day for three weeks) causes a dramatic reduction of tumors in both skeleton and visceral organs in SCID mice.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 419.95
Formula C25H26ClN3O
CAS Number 1380392-05-1
Purity >99%
Solubility DMSO ≥ 10 mg/mL
Storage 2-8°C, protect from light, dry, sealed
References

[1] Fei Shen, et al. Mol Cancer Res. Novel Small-Molecule CX3CR1 Antagonist Impairs Metastatic Seeding and Colonization of Breast Cancer Cells

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: JMS-17-2 supplier, CXCR, inhibitors

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