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SX-682

Cat. No. M9821
SX-682 Structure
Synonym:

SX682

Size Price Availability Quantity
5mg USD 150 In stock
10mg USD 265 In stock
25mg USD 530 In stock
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Quality Control
Biological Activity

SX-682 is a potent and selective CXCR1/2 allosteric inhibitor, it may be useful for castration-resistant prostate cancer. SX-682 can block tumor myeloid-derived suppressor cells (MDSCs) recruitment and enhance T cell activation and antitumor immunity. CXCR1 and CXCR2 chemokine receptors and their ligands (CXCL1/2/3/7/8) play an important role in tumor progression.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 467.2
Formula C19H14BF4N3O4S
CAS Number 1648843-04-2
Purity >98%
Solubility DMSO ≥ 120 mg/mL
Storage at -20°C
References

Inhibiting myeloid-derived suppressor cell trafficking enhances T cell immunotherapy
Lillian Sun, et al. JCI Insight. 2019 Apr 4;4(7):e126853. PMID: 30944253.

Effective combinatorial immunotherapy for castration-resistant prostate cancer
Xin Lu, et al. Nature. 2017 Mar 30;543(7647):728-732. PMID: 28321130.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SX-682, SX682 supplier, CXCR, inhibitors

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