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Balixafortide

Cat. No. M27720

All AbMole products are for research use only, cannot be used for human consumption.

Balixafortide Structure
Synonym:

POL6326

Size Price Availability Quantity
5mg USD 170  USD170 In stock
10mg USD 300  USD300 In stock
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Quality Control & Documentation
Biological Activity

Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM. Balixafortide shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide blocks β-arrestin recruitment and calcium flux with IC50s < 10 nM. Balixafortide is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects.

Chemical Information
Molecular Weight 1864.14
Formula C84H118N24O21S2
CAS Number 1051366-32-5
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Tyler Robinson, et al. Prostate. A CXCR4 inhibitor (balixafortide) enhances docetaxel-mediated antitumor activity in a murine model of prostate cancer bone metastasis

[2] Gokhan Batur, et al. Chimia (Aarau). Macrocycle Therapeutics to Treat Life-threatening Diseases

[3] Miao Miao, et al. Expert Opin Drug Metab Toxicol. Clinical significance of chemokine receptor antagonists

[4] Sonia Pernas, et al. Lancet Oncol. Balixafortide plus eribulin in HER2-negative metastatic breast cancer: a phase 1, single-arm, dose-escalation trial

[5] Darja Karpova, et al. J Transl Med. Mobilization of hematopoietic stem cells with the novel CXCR4 antagonist POL6326 (balixafortide) in healthy volunteers-results of a dose escalation trial

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Keywords: Balixafortide, POL6326 supplier, CXCR, inhibitors, activators

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