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ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4). ATI-2341 activates the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization.
| Cell Experiment | |
|---|---|
| Cell lines | HEK-293 cells |
| Preparation method | Receptors(CXCR4-eGFP) are transiently transfected into HEK-293 cells and are plated 24 h after transfection on glass coverslips coated with poly-D-lysine. The next day, cells are treated with either vehicle alone or with varying concentrations of ATI-2341 for 30 min at 37 °C followed by fixation with methanol for 5 min at -20 °C. GFP fluorescence is visualized directly using a Zeiss Axiovert inverted microscope. Images are processed using Adobe Photoshop and Adobe Illustrator. |
| Concentrations | 0, 0.031, 0.125, 0.25, 0.5, 1 μM |
| Incubation time | 30 min |
| Animal Experiment | |
|---|---|
| Animal models | BALB/c mice |
| Formulation | - |
| Dosages | 300 nmol/kg |
| Administration | i.p. |
| Molecular Weight | 2370.84 |
| Formula | C106H179F3N26O27S2 |
| CAS Number | 1337878-62-2 (free base) |
| Solubility (25°C) | DMSO 100 mg/mL |
| Storage | -20°C, sealed |
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