Free shipping on all orders over $ 500

ATI-2341 TFA

Cat. No. M10141
ATI-2341 TFA Structure
Size Price Availability Quantity
1mg USD 126  USD140 In stock
5mg USD 342  USD380 In stock
10mg USD 531  USD590 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4). ATI-2341 activates the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization.

Cell Experiment
Cell lines HEK-293 cells
Preparation method Receptors(CXCR4-eGFP) are transiently transfected into HEK-293 cells and are plated 24 h after transfection on glass coverslips coated with poly-D-lysine. The next day, cells are treated with either vehicle alone or with varying concentrations of ATI-2341 for 30 min at 37 °C followed by fixation with methanol for 5 min at -20 °C. GFP fluorescence is visualized directly using a Zeiss Axiovert inverted microscope. Images are processed using Adobe Photoshop and Adobe Illustrator.
Concentrations 0, 0.031, 0.125, 0.25, 0.5, 1 μM
Incubation time 30 min
Animal Experiment
Animal models BALB/c mice
Formulation -
Dosages 300 nmol/kg
Administration i.p.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 2370.84
Formula C106H179F3N26O27S2
CAS Number 1337878-62-2 (free base)
Purity >98%
Solubility DMSO 100 mg/mL
Storage -20°C, sealed

Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein
Julie Quoyer, et al. Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):E5088-97. PMID: 24309376.

Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells
Boris Tchernychev, et al. Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22255-9. PMID: 21139054.

Related CXCR Products

LY2510924 is a potent and selective CXCR4 antagonist, which blocks SDF-1 binding to CXCR4 with IC50 of 0.079 nM.

Motixafortide (BL-8040)

Motixafortide (BL-8040) is an antagonist of CXCR4 with IC50 value of 1 nM.


SX-682 is a potent and selective CXCR1/2 allosteric inhibitor, it may be useful for castration-resistant prostate cancer.

VUF11207 fumarate

VUF11207 fumarate is a CXCR7 agonist and a high-potency CXCR7 ligand (pKi=8.1).


JMS-17-2 is a potent and selective CX3CR1 antagonist with IC50 of 0.32 nM.

Abmole Inhibitor Catalog 2017

Keywords: ATI-2341 TFA supplier, CXCR, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.