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Sardomozide dihydrochloride (also known as SAM486A or CGP48664) is a second-generation polyamine synthesis inhibitor, which inhibits the activity of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC). Sardomozide inhibits SAMDC with an IC50 of 5 nM in cell assay. Intracellular SAMDC activity is reduced to 10% of control after treatment for 48 hours with 3 μM Sardomozide.
| Molecular Weight | 303.19 |
| Formula | C11H16Cl2N6 |
| CAS Number | 138794-73-7 |
| Solubility (25°C) | DMSO ≥ 10 mg/mL Water 4 mg/mL |
| Storage | -20°C, dry, sealed |
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