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Azimilide is an investigational class III anti-arrhythmic compound that blocks fast and slow components of the delayed rectifier cardiac potassium channels. It inhibits KV7.1 and KV11.1 potassium channels. Azimilide′s block of K+ currents is relatively selective for IKr over IKs: It potently blocks the rapidly activating component of the delayed rectifier, IKr (IC50 0.4 mM), and inhibits IKs (IC50 3 mM) with nearly 10-fold less potency. At 10 mM, it does not block the inward rectifier K+ current. It blocks (10 mM) the L-type Ca2+ current (ICa) in a use-dependent manner.
| Molecular Weight | 530.88 |
| Formula | C23H28ClN5O3 · 2HCl |
| CAS Number | 149888-94-8 |
| Solubility (25°C) | DMSO: 1 mg/mL (warmed) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Mark Carlson. Azimilide dihydrochloride
[2] H T Tran. Azimilide dihydrochloride: a unique class III antiarrhythmic agent
[3] R Abrol, et al. Azimilide dihydrochloride: a new class III anti-arrhythmic agent
[4] D Clemett, et al. Azimilide
[5] R Karam, et al. Azimilide dihydrochloride, a novel antiarrhythmic agent
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