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Tolfenamic Acid

Cat. No. M3362
Tolfenamic Acid Structure
Synonym:

GEA 6414

Size Price Availability Quantity
500mg USD 45  USD45 In stock
1g USD 60  USD60 In stock
5g USD 120  USD120 In stock
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Quality Control & Documentation
Biological Activity

Tolfenamic Acid is a COX-2 inhibitor, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1. Tolfenamic Acid (GEA 6414) also acts as a potent Sp protein inhibitor, decreases Sp1 and Sp4 and suppresses c-Met expression in esophageal cancer cells BE3 and SKGT5.

Chemical Information
Molecular Weight 261.7
Formula C14H12ClNO2
CAS Number 13710-19-5
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Erdinc Turk, et al. Pharmacokinetics of tolfenamic acid in goats after different administration routes

[2] Huiming Zhang, et al. Tolfenamic acid inhibits GSK-3β and PP2A mediated tau hyperphosphorylation in Alzheimer's disease models

[3] Sofia Ahmed, et al. Tolfenamic Acid

[4] Jose M Cornejo-Montes-de-Oca, et al. Tolfenamic Acid Prevents Amyloid β-induced Olfactory Bulb Dysfunction In Vivo

[5] David Feldman, et al. Chemopreventive Properties of Tolfenamic Acid: A Mechanistic Review

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  Catalog
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Keywords: Tolfenamic Acid, GEA 6414 supplier, COX, inhibitors, activators


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