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COX Cyclooxygenase

Inhibitors

Cat.No.  Name Information
M3264 Pravadoline Pravadoline (WIN 48098) is a cyclooxygesase inhibitor and inhibits prostaglandin synthesis with IC50 of 4.9 μM, also a cannabinoid agonist.
M2495 Carprofen Carprofen inhibits canine COX2 with IC50 of 0.03 mM.
M3359 Ibuprofen Ibuprofen (Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively.
M21500 Polmacoxib Polmacoxib (CG100649) is a first-in-class, orally active non-steroidal anti-inflammatory compound (NSAID) that acts as a dual inhibitor. It inhibited COX-2 (IC50 ~ 0.1 μg/ml) and carbonic anhydrase.
M21079 Loxoprofenol-SRS tromethamine Loxoprofenol-SRS tromethamine (HR1405-01) is an intravenous NSAID with good anti-inflammatory and analgesic activity.
M20850 Ibuprofen Lysine Ibuprofen Lysine is a non-steroidal anti-inflammatory drug.
M20792 Bromfenac sodium hydrate Bromfenac sodium hydrate (Bromsite, Bromday, Prolensa, Xibrom), a brominated nonsteroidal anti-inflammatory drugs (NSAID) with strong in vitro anti-inflammatory potency, is a potent and orally active inhibitor of COX with IC50 of 5.56 nM and 7.45 nM for COX-1 and COX-2, respectively.
M20790 S-(+)-Ketoprofen S-(+)-Ketoprofen (Compound 1, Actron, (S)-Ketoprofen, Dexketoprofen) is a potent inhibitor of cyclooxygenase (COX) with IC50 of 1.9 nM and 27 nM for COX-1 and COX-2, respectively.
M20772 Pamicogrel Pamicogrel (KBT3022) is an inhibitor of cyclooxygenase (COX) with platelet anti-aggregatory properties.
M20769 Desmethyl Celecoxib Desmethyl Celecoxib (compound 3b), an analog of Celecoxib with the optimal yield of 75%, is a selective inhibitor of cyclooxygenase-2 (COX-2) with anti-inflammatory activities.
M20698 Mavacoxib Mavacoxib is a selective, long-acting cyclooxygenase-2 (COX-2) inhibitor. Mavacoxib is a novel nonsteroidal anti-inflammatory drug (NSAID).
M20573 Flurbiprofen Axetil Flurbiprofen Axetil is one of the commonly used nonsteroidal anti-inflammatory drugs (NSAIDs) that nonselectively inhibits cyclooxygenase.
M20527 Deracoxib Deracoxib is a COX-2 inhibitor with >48-fold selectivity over COX-1. It also exhibits inhibitory activity against phosphodiesterase (Ki = 3.6 μM against human PDE4D3).
M20500 Phenidone Phenidone, a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound that is primarily used as a photographic developer.
M20423 Etoricoxib Etoricoxib is a new COX-2 selective inhibitor with anti-inflammatory, antipyretic, analgesic, and potential antineoplastic properties.
M14084 Salicin Salicin is a natural COX inhibitor.
M14083 Paradol Paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants. Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX)-2 active site.
M14082 Naproxen Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay.
M14081 Indomethacin sodium hydrate Indomethacin sodium hydrate (Indometacin sodium hydrate) is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells.
M14080 Gallic acid hydrate Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2).
M14079 Etoricoxib-d4 Etoricoxib D4 (MK-0663 D4) is a deuterium labeled Etoricoxib. Etoricoxib is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.
M11449 AG-024322 Ag-024322 is a potent ATP-competitive pan-CDK inhibitor that inhibits THE Ki values of CDK1, CDK2, and CDK4 in the 1-3 nM range. Ag-024322 showed broad spectrum antitumor activity and clear target regulation in vivo. Ag-024322 induced apoptosis.
M11002 N-tert-Butyl-α-phenylnitrone N-tert-Butyl-α-phenylnitrone is a nitrokeone-based free radical scavenger that forms a nitric oxide spin adduct. N-tert-Butyl-α-phenylnitrone inhibits the catalytic activity of COX2.



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