Cat.No. | Name | Information |
---|---|---|
M20423 | Etoricoxib | Etoricoxib is a new COX-2 selective inhibitor with anti-inflammatory, antipyretic, analgesic, and potential antineoplastic properties. |
M3936 | Saikosaponin D | Saikosaponin D is a COX-2 and iNOS inhibitor,a Saikosaponin A epimer, which Inhibits NF-κB, TNF-α, IL-1β and IL-6 and Inhibits apoptosis. |
M3471 | Ketorolac | Ketorolac (Ketorolac tromethamine) is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively. |
M3359 | Ibuprofen | Ibuprofen (Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively. |
M3264 | Pravadoline | Pravadoline (WIN 48098) is a cyclooxygesase inhibitor and inhibits prostaglandin synthesis with IC50 of 4.9 μM, also a cannabinoid agonist. |
M2824 | Lumiracoxib | Lumiracoxib is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. |
M2495 | Carprofen | Carprofen inhibits canine COX2 with IC50 of 0.03 mM. |
M1965 | Celecoxib | Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor (IC50 values are 15 and 0.04 μM for COX-1 and COX-2 respectively). |
M44665 | (±)-Catechin | (±)-Catechin (rel-Cianidanol) is the racemate of Catechin. |
M30270 | γ-Tocopherol | γ-Tocopherol (D-γ-Tocopherol) is a potent cyclooxygenase (COX) inhibitor. γ-Tocopherol is a naturally occurring form of Vitamin E in many plant seeds, such as corn oil and soybeans. γ-Tocopherol possesses antiinflammatory properties and anti-cancer activity. |
M21500 | Polmacoxib | Polmacoxib (CG100649) is a first-in-class, orally active non-steroidal anti-inflammatory compound (NSAID) that acts as a dual inhibitor. It inhibited COX-2 (IC50 ~ 0.1 μg/ml) and carbonic anhydrase. |
M20698 | Mavacoxib | Mavacoxib is a selective, long-acting cyclooxygenase-2 (COX-2) inhibitor. Mavacoxib is a novel nonsteroidal anti-inflammatory drug (NSAID). |
M19417 | Humulone | Humulone (α-Lupulic acid) is a potent cyclooxygenase-2 (COX-2) inhibitor. Humulone acts as a positive modulator of GABAA receptor at low micromolar concentrations. |
M19356 | Columbin | Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits COX-2 (EC50=53.1 μM) over COX-1 (EC50=327 μM). |
M14083 | Paradol | Paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants. Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX)-2 active site. |
M14080 | Gallic acid hydrate | Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2). |
M11002 | N-tert-Butyl-α-phenylnitrone | N-tert-Butyl-α-phenylnitrone is a nitrokeone-based free radical scavenger that forms a nitric oxide spin adduct. N-tert-Butyl-α-phenylnitrone inhibits the catalytic activity of COX2. |
M10989 | (+)-Catechin hydrate | (+)-Catechin hydrate inhibits cyclooxygenase-1 (COX-1), with IC50 of 1.4 μM. |
M10920 | Chebulagic acid | Chebulagic acid is a dual inhibitor of COX-LOX extracted from the fruit. Has anti-inflammatory and anti-infective effects. Chebulagic acid is an M2(S31N) inhibitor and anti-influenza virus agent. Chebulagic acid also inhibits replication of the SARS-CoV-2 virus,EC50 The value is 9.76 μM. |
M10580 | Guaiacol | Guaiacol is a phenolic compound, which inhibits LPS-stimulated COX-2 expression and NF-κB activation, with anti-inflammatory activity. |
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