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COX Cyclooxygenase

Inhibitors

Cat.No.  Name Information
M3264 Pravadoline Pravadoline (WIN 48098) is a cyclooxygesase inhibitor and inhibits prostaglandin synthesis with IC50 of 4.9 μM, also a cannabinoid agonist.
M2495 Carprofen Carprofen inhibits canine COX2 with IC50 of 0.03 mM.
M3359 Ibuprofen Ibuprofen (Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively.
M11449 AG-024322 Ag-024322 is a potent ATP-competitive pan-CDK inhibitor that inhibits THE Ki values of CDK1, CDK2, and CDK4 in the 1-3 nM range. Ag-024322 showed broad spectrum antitumor activity and clear target regulation in vivo. Ag-024322 induced apoptosis.
M11002 N-tert-Butyl-α-phenylnitrone N-tert-Butyl-α-phenylnitrone is a nitrokeone-based free radical scavenger that forms a nitric oxide spin adduct. N-tert-Butyl-α-phenylnitrone inhibits the catalytic activity of COX2.
M10989 (+)-Catechin hydrate (+)-Catechin hydrate inhibits cyclooxygenase-1 (COX-1), with IC50 of 1.4 μM。
M10920 Chebulagic acid Chebulagic acid is a dual inhibitor of COX-LOX extracted from the fruit. Has anti-inflammatory and anti-infective effects. Chebulagic acid is an M2(S31N) inhibitor and anti-influenza virus agent. Chebulagic acid also inhibits replication of the SARS-CoV-2 virus,EC50 The value is 9.76 μM.
M10580 Guaiacol Guaiacol is a phenolic compound, which inhibits LPS-stimulated COX-2 expression and NF-κB activation, with anti-inflammatory activity.
M10099 CAY10404 CAY10404 is one of the most selective inhibitors of COX-2 (IC50 = 1 nM) over COX-1.
M9682 TFAP TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor with IC50 of 0.8 μM.
M7051 NS 398 NS 398 is a cyclooxygenase-2 (COX-2) inhibitor.
M6057 α-Vitamin E α-Vitamin E ((+)-α -tocopherol) is a naturally occurring form of Vitamin E that is a potent antioxidant.
M5996 Tenoxicam Tenoxicam is a good HO. radicals scavenger with an IC50 of 56.7 μM.
M5985 Suprofen Suprofen is a dual COX-1/COX-2 inhibitor, used as a non-steroidal anti-inflammatory analgesic and antipyretic.
M5945 Salicylic acid Salicylic acid is a beta hydroxy acid that occurs as a natural compound in plants which is an inhibitor of ethylene biosynthesis and cyclooxygenase activity.
M5907 Propyphenazone Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.
M5893 Pranoprofen Pranoprofen is a non-steroidal COX inhibitor, used as an anti-inflammatory drug in ophthalmology.
M5874 Phenacetin Phenacetin is a non-opioid analgesic without anti-inflammatory properties.
M5859 Parecoxib Sodium Parecoxib is a potent and selective COX-2 inhibitor.
M5858 Parecoxib Parecoxib is a selective COX2 inhibitor.
M5814 Niflumic acid Niflumic acid is an inhibitor of cyclooxygenase-2 used for joint and muscular pain.
M5755 Loxoprofen Loxoprofen is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group.
M5703 Iguratimod Iguratimod(T-614) is a selective inhibitor of cyclo-oxygenase-2 (COX-2), and inhibits the production of interleukin-1 (IL-1), IL-6, IL-8 and tumour necrosis factor.



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