| Cat.No. | Name | Information |
|---|---|---|
| M3264 | Pravadoline | Pravadoline (WIN 48098) is a cyclooxygesase inhibitor and inhibits prostaglandin synthesis with IC50 of 4.9 μM, also a cannabinoid agonist. |
| M2495 | Carprofen | Carprofen inhibits canine COX2 with IC50 of 0.03 mM. |
| M3359 | Ibuprofen | Ibuprofen (Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively. |
| M3936 | Saikosaponin D | Saikosaponin D is a COX-2 and iNOS inhibitor,a Saikosaponin A epimer, which Inhibits NF-κB, TNF-α, IL-1β and IL-6 and Inhibits apoptosis. |
| M1965 | Celecoxib | Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor (IC50 values are 15 and 0.04 μM for COX-1 and COX-2 respectively). |
| M3471 | Ketorolac | Ketorolac (Ketorolac tromethamine) is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively. |
| M20423 | Etoricoxib | Etoricoxib is a new COX-2 selective inhibitor with anti-inflammatory, antipyretic, analgesic, and potential antineoplastic properties. |
| M2824 | Lumiracoxib | Lumiracoxib is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. |
| M4547 | Roburic-acid | Roburic acid is a tetracyclic triterpenoid in Gentiana macrophylla. As an inhibitor of COX, the IC50 values of COX-1 and COX-2 are 5 and 9 μM, respectively. |
| M4445 | Prim-o-glucosylcimifugin | Prim-o-glucosylcimifugin has a potent anti-inflammatory effect. INOS and COX-2 expression could be inhibited by regulating JAK2/STAT3 signal transduction. |
| M4437 | Rutaecarpine | Rutaecarpine is a delayed rectifier K+ channel blocker, inhibits platelet aggregation. |
| M4284 | Harpagoside | Harpagoside was separated from Harpagophytum procumbens (Hp). Harpagoside inhibited COX-1 and COX-2 activity and NO production. |
| M4212 | CG | (-) -catechin gallate is a microcomponent of green tea Catechin. (-) -catechin gallate inhibited COX-1 and COX-2 activities. |
| M4209 | ECG | ECG |
| M4207 | (-)Epicatechin | Epicatechin inhibited coX-1 with IC50 of 3.2 μM. (-)Epicatechin inhibits il-1 β -induced iNOS expression by blocking nuclear localization of NF-κB p65 subunit. |
| M4125 | 8-Shogaol | [8]-Shogaol, an irritant phenolic compound from ginger, has antiplatelet activity (IC50=5 μM) and inhibition of COX-2 (IC50=17.5 μM). [8]-Shogaol induces apoptosis of human leukemia cells. |
| M4088 | Ginsenoside Compound-K | Ginsenoside Compound-K is a bacterial metabolite of G-Rb1, exhibits anti-inflammatory effects by reducing iNOS and COX-2. |
| M3994 | Hederagenin | Hederagenin is a derivative of oleanolic acid isolated from the leaves of ivy (Hedera helix L.) that has been shown to have potential anti-tumor activity. Hederagenin can inhibit LPS-stimulated expression of iNOS, COX-2, and NF-κB. |
| M3809 | Isofraxidin | Isofraxidin is an anti-bacterial, anti-oxidant, and anti-inflammatory agent, it acts by reducing the levels of tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), and prostaglandin E2 (PGE2), inhibiting cyclooxygenase-2 (COX-2) protein expression. |
| M3614 | FK-3311 | Fk3311 is a selective inhibitor of COX-2. Anti-inflammatory compounds. |
| M3608 | Naproxen sodium | Naproxen is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively. |
| M3554 | Fenoprofen Calcium | Fenoprofen Calcium is a nonsteroidal, anti-inflammatory antiarthritic agent. |
| M3439 | Licofelone | Licofelone is a dual COX/LOX inhibitor being considered as a treatment for osteoarthritis. |
| M3430 | Phenylbutazone | Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis. |
| M3429 | Piroxicam | Piroxicam is a non-selective COX inhibitor with an IC50 of 6 mM. |
| M3420 | Diclofenac Sodium | Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively. |
| M3398 | Nimesulide | Nimesulide is a relatively COX-2 selective inhibitor with IC50 of 26 μM. |
| M3391 | Ketoprofen | Ketoprofen is a non-selective NSAID with IC50 of 0.5 μM and 2.33 μM for human recombinant COX-1 and COX-2, respectively. |
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