| Cat.No. | Name | Information |
|---|---|---|
| M3264 | Pravadoline | Pravadoline (WIN 48098) is a cyclooxygesase inhibitor and inhibits prostaglandin synthesis with IC50 of 4.9 μM, also a cannabinoid agonist. |
| M2495 | Carprofen | Carprofen inhibits canine COX2 with IC50 of 0.03 mM. |
| M3359 | Ibuprofen | Ibuprofen (Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively. |
| M3936 | Saikosaponin D | Saikosaponin D is a COX-2 and iNOS inhibitor,a Saikosaponin A epimer, which Inhibits NF-κB, TNF-α, IL-1β and IL-6 and Inhibits apoptosis. |
| M3466 | Indomethacin | Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin can be used for cancer, inflammation and viral infection research. |
| M1965 | Celecoxib | Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor (IC50 values are 15 and 0.04 μM for COX-1 and COX-2 respectively). |
| M3471 | Ketorolac tromethamine salt | Ketorolac tromethamine salt (Ketorolac tromethamine) is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively. |
| M20423 | Etoricoxib | Etoricoxib is a new COX-2 selective inhibitor with anti-inflammatory, antipyretic, analgesic, and potential antineoplastic properties. |
| M2824 | Lumiracoxib | Lumiracoxib is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. |
| M3915 | Catechin | Catechin (Cianidanol) is a flavan-3-ol, a type of natural phenol and antioxidant. Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. |
| M5366 | 4-Aminoantipyrine | 4-Aminoantipyrine(Ampyrone) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. |
| M5361 | 2-Ethoxybenzamide | 2-ethoxybenzamide is a common analgesic and anti-inflammatory compound used to relieve fever, fever, headache and other mild pain. |
| M5352 | (R)-(-)-Ibuprofen | (R)-Ibuprofen, a nonsteroidal anti-inflammatory, is the less active enantiomer of ibuprofen, an inhibitor of Cox-1 and Cox-2. |
| M5351 | Sulfinpyrazone | Sulfinpyrazone is one of the most studied platelet COX inhibitors, also a uricosuric agent that competitively inhibits uric acid reabsorption in kidney proximal tubules. |
| M5185 | Xanthohumol | Xanthohumol is an inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV). |
| M4761 | Avicularin | Avicularin is a bioactive flavonoid found in a variety of plants. It has anti-inflammatory, anti-allergy, anti-oxidation, liver protection, anti-tumor and other effects. Avicularin inhibits NF-κB (p65), COX-2 and PPAR-γ activities. In LPS-stimulated RAW 264.7 macrophages, Avicularin produces anti-inflammatory activity by inhibiting the ERK signaling pathway. |
| M4673 | Esculentoside-A | Esculentoside A (EsA), a triterpenoid saponin isolated from the root of Phytolacca esculenta. Esculentoside A (EsA) possesses anti-inflammatory activity in acute and chronic experimental models[2], has selective inhibitory activity towards cyclooxygenase-2 (COX-2). |
| M4667 | Homoorientin | Homoorientin (Isoorientin) is a potent inhibitor of COX-2 with an IC50 value of 39 μM. |
| M4655 | Byakangelicol | Byakangelicol is white triol separated from Angelica dahurica, Interleukin-1 β (IL-1β) -induced release of prostaglandin E2 (PGE2) in A549 cells was inhibited by inhibiting the expression and activity of coX-2. Byakangelicol can be used to study airway inflammation. |
| M4547 | Roburic-acid | Roburic acid is a tetracyclic triterpenoid in Gentiana macrophylla. As an inhibitor of COX, the IC50 values of COX-1 and COX-2 are 5 and 9 μM, respectively. |
| M4445 | Prim-o-glucosylcimifugin | Prim-o-glucosylcimifugin has a potent anti-inflammatory effect. INOS and COX-2 expression could be inhibited by regulating JAK2/STAT3 signal transduction. |
| M4437 | Rutaecarpine | Rutaecarpine is a delayed rectifier K+ channel blocker, inhibits platelet aggregation. |
| M4284 | Harpagoside | Harpagoside was separated from Harpagophytum procumbens (Hp). Harpagoside inhibited COX-1 and COX-2 activity and NO production. |
| M4212 | CG | (-) -catechin gallate is a microcomponent of green tea Catechin. (-) -catechin gallate inhibited COX-1 and COX-2 activities. |
| M4209 | ECG | ECG |
| M4207 | (-)Epicatechin | Epicatechin inhibited coX-1 with IC50 of 3.2 μM. (-)Epicatechin inhibits il-1 β -induced iNOS expression by blocking nuclear localization of NF-κB p65 subunit. |
| M4125 | 8-Shogaol | [8]-Shogaol, an irritant phenolic compound from ginger, has antiplatelet activity (IC50=5 μM) and inhibition of COX-2 (IC50=17.5 μM). [8]-Shogaol induces apoptosis of human leukemia cells. |
| M4088 | Ginsenoside Compound-K | Ginsenoside Compound-K is a bacterial metabolite of G-Rb1, exhibits anti-inflammatory effects by reducing iNOS and COX-2. |
| M3994 | Hederagenin | Hederagenin is a derivative of oleanolic acid isolated from the leaves of ivy (Hedera helix L.) that has been shown to have potential anti-tumor activity. Hederagenin can inhibit LPS-stimulated expression of iNOS, COX-2, and NF-κB. |
| M3915 | Catechin | Catechin (Cianidanol) is a flavan-3-ol, a type of natural phenol and antioxidant. Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. |
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