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Diclofenac

Cat. No. M5572
Diclofenac  Structure
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1g USD 50  USD50 In stock
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Quality Control & Documentation
Biological Activity

Diclofenac (diclofenac) is a COX inhibitor and has an IC50 of 60 and 220 nM for sheep COX-1 and -2, respectively.

Chemical Information
Molecular Weight 296.15
Formula C14H11Cl2NO2
CAS Number 15307-86-5
Solubility (25°C) 3.5 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Altman R, et al. Drugs. Advances in NSAID development: evolution of diclofenac products using pharmaceutical technology.

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  Catalog
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Keywords: Diclofenac supplier, COX, inhibitors, activators


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