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COX Cyclooxygenase

Cat.No.  Name Information
M3264 Pravadoline Pravadoline (WIN 48098) is a cyclooxygesase inhibitor and inhibits prostaglandin synthesis with IC50 of 4.9 μM, also a cannabinoid agonist.
M2495 Carprofen Carprofen inhibits canine COX2 with IC50 of 0.03 mM.
M3359 Ibuprofen Ibuprofen (Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively.
M3936 Saikosaponin D Saikosaponin D is a COX-2 and iNOS inhibitor,a Saikosaponin A epimer, which Inhibits NF-κB, TNF-α, IL-1β and IL-6 and Inhibits apoptosis.
M1965 Celecoxib Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor (IC50 values are 15 and 0.04 μM for COX-1 and COX-2 respectively).
M3471 Ketorolac Ketorolac (Ketorolac tromethamine) is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively.
M20423 Etoricoxib Etoricoxib is a new COX-2 selective inhibitor with anti-inflammatory, antipyretic, analgesic, and potential antineoplastic properties.
M2824 Lumiracoxib Lumiracoxib is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1.
M3362 Tolfenamic Acid Tolfenamic Acid is a COX-2 inhibitor, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.
M3360 Zaltoprofen Zaltoprofen is an orally active COX inhibitor with IC50 values of 1.3 and 0.34 μM for COX-1 and COX-2, respectively, and possesses potent anti-inflammatory activity.
M3308 Asaraldehyde Asaraldehyde is a natural COX-2 inhibitor, exhibiting 17-fold selectivity over COX-1.
M3203 Lornoxicam Lornoxicam is a COX-1 and COX-2 inhibitor with IC50 of 5 nM and 8 nM, respectively.
M3148 ATB 346 ATB-346 is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.
M3112 Valdecoxib Valdecoxib is a potent and selective inhibitor of COX-2 with IC50 of 5 nM.
M3089 Triflusal Triflusal irreversibly inhibits the production of thromboxane-B2 in platelets by acetylating cycloxygenase-1.
M3079 Tolmetin Sodium Tolmetin Sodium is an aromatic alkyic acid non - steroidal anti - inflammatory compound.
M3024 Sodium salicylate Sodium salicylate is used in medicine as an analgesic and antipyretic.
M2984 Rofecoxib Rofecoxib is a COX-2 inhibitor with IC50 of 18 nM.
M2905 Oxaprozin Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory compound (NSAID) used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis.
M2871 Nabumetone Nabumetone is a non-steroidal anti-inflammatory compound and its active metabolite inhibits the COX.
M2835 Mefenamic Acid Mefenamic Acid is a competitive inhibitor of COX-1 and COX-2.
M2817 Meclofenamate sodium Meclofenamate sodium is a dual COX-1/COX-2 inhibitor with an IC50 of 40 nM and 50 nM, respectively. used in the study of joint and muscle pain, arthritis, and dysmenorrhea. meclofenamate sodium is a non-selective gap-junction blocker and a highly selective inhibitor of adipose and obesity-associated enzyme (FTO) inhibitor.
M2706 Flufenamic acid Flufenamic Acid is an anti-inflammatory agent, and also acts as an ion channel modulator.
M2634 Diclofenac Potassium Diclofenac potassium is a nonsteroidal anti-inflammatory compound taken to reduce inflammation and as an analgesic reducing pain in certain conditions.
M2633 Diclofenac Diethylamine Diclofenac diethylamine is a nonsteroidal anti-inflammatory compound taken to reduce inflammation and as an analgesic reducing pain in certain conditions.
M2478 Bufexamac Bufexamac is a COX inhibitor for IFN-α release with EC50 of 8.9 μM.
M2471 Bromfenac Sodium Bromfenac is a nonsteroidal anti-inflammatory compound (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.
M2392 Ampiroxicam Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory compound.




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