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Isofraxidin

Cat. No. M3809
Isofraxidin Structure
Synonym:

IFD

Size Price Availability Quantity
5mg USD 55  USD55 In stock
10mg USD 90  USD90 In stock
20mg USD 160  USD160 In stock
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Quality Control & Documentation
Biological Activity

Isofraxidin is an anti-bacterial, anti-oxidant, and anti-inflammatory agent, it acts by reducing the levels of tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), and prostaglandin E2 (PGE2), inhibiting cyclooxygenase-2 (COX-2) protein expression. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells.

Chemical Information
Molecular Weight 222.19
Formula C11H10O5
CAS Number 486-21-5
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jialei Jin, et al. Food Funct. Isofraxidin targets the TLR4/MD-2 axis to prevent osteoarthritis development

[2] Taisuke Yamazaki, et al. Biol Pharm Bull. Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits matrix metalloproteinase-7 expression and cell invasion of human hepatoma cells

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Keywords: Isofraxidin, IFD supplier, COX, inhibitors, activators


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