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Valdecoxib is a potent and selective inhibitor of COX-2 with IC50 of 5 nM.
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
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| Animal models | Male Sprague-Dawley rats |
| Formulation | 0.5% methyl cellulose and 0.025% Tween-20 |
| Dosages | 10.2 mg/kg |
| Administration | Orally |
| Molecular Weight | 314.36 |
| Formula | C16H14N2O3S |
| CAS Number | 181695-72-7 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Yannik Bluhm, et al. Valdecoxib blocks rat TRPV2 channels
[2] No authors listed. Valdecoxib
[3] A J Scheen, et al. Valdecoxib (Bextra)
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|---|
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Sudoxicam is a reversible and orally active COX antagonist and a non-steroidal anti-inflammatory agent from the enol-carboxamide class. |
| Metyrosine
Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine significantly inhibits high COX-2 activity. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. |
| PPOH
PPOH, a fatty acid derivative, is a selective cyclooxygenase (COX) inhibitor that inhibits arachidonic acid cyclooxygenase activity in renal cortical microsomes. |
| Tenidap
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| COX-2-IN-6
COX-2-IN-6 is an orally active, gut-restricted and selective cyclooxygenase-2 (COX-2) inhibitor for colorectal Chemoprevention of cancer. |
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