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Licofelone

Cat. No. M3439
Licofelone Structure
Synonym:

ML3000

Size Price Availability Quantity
5mg USD 60  USD60 In stock
10mg USD 110  USD110 In stock
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Quality Control & Documentation
Biological Activity

Licofelone is a dual COX/LOX inhibitor being considered as a treatment for osteoarthritis.

Chemical Information
Molecular Weight 379.88
Formula C23H22ClNO2
CAS Number 156897-06-2
Solubility (25°C) DMSO 70 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Seyed Mehrad Razavi, et al. Licofelone, a potent COX/5-LOX inhibitor and a novel option for treatment of neurological disorders

[2] Vahid Nikoui, et al. Licofelone, a dual cyclooxygenase/5-lipoxygenase inhibitor, reverses endotoxin-induced impaired atrial chronotropic responsiveness to cholinergic stimulation in rats

[3] Shrinivas K Kulkarni, et al. Licofelone: the answer to unmet needs in osteoarthritis therapy?

[4] S K Kulkarni, et al. Licofelone--a novel analgesic and anti-inflammatory agent

[5] J M Alvaro-Gracia. Licofelone--clinical update on a novel LOX/COX inhibitor for the treatment of osteoarthritis

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  Catalog
Abmole Inhibitor Catalog




Keywords: Licofelone, ML3000 supplier, COX, inhibitors, activators


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