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Ketoprofen

Cat. No. M3391
Ketoprofen Structure
Size Price Availability Quantity
100mg USD 40  USD40 In stock
500mg USD 50  USD50 In stock
1g USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Ketoprofen (Actron) is a non-selective NSAID exhibiting IC50 of 0.5 μM and 2.33 μM for human recombinant COX-1 and COX-2, respectively. It is used for its antipyretic, analgesic, and anti-inflammatory properties by inhibiting cyclooxygenase-1 and -2 (COX-1 and COX-2) enzymes reversibly, which decreases production of pro-inflammatory prostaglandin precursors. Based on in vitro IC (50) COX-1:IC (50) COX-2 ratios, robenacoxib was COX-2 selective (ratio=32.2), diclofenac (ratio=3.9) and meloxicam (ratio=2.7) were only weakly COX-2 preferential, and ketoprofen (ratio=0.049) was COX-1 selective.

Chemical Information
Molecular Weight 254.28
Formula C16H14O3
CAS Number 22071-15-4
Solubility (25°C) DMSO 46 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jun Wang, et al. Targeted eco-pharmacovigilance for ketoprofen in the environment: Need, strategy and challenge

[2] Tiffany Yvonne Loh, et al. Ketoprofen-induced photoallergic dermatitis

[3] Carmen Cantisani, et al. Ketoprofen allergic reactions

[4] Bernard Mazires. Topical ketoprofen patch

[5] B Avouac, et al. Ketoprofen: the European experience

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  Catalog
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Keywords: Ketoprofen supplier, COX, inhibitors, activators


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