COX Cyclooxygenase

Cat.No.	Name	Information
M3264	Pravadoline	Pravadoline (WIN 48098) is a cyclooxygesase inhibitor and inhibits prostaglandin synthesis with IC50 of 4.9 μM, also a cannabinoid agonist.
M2495	Carprofen	Carprofen inhibits canine COX2 with IC50 of 0.03 mM.
M3359	Ibuprofen	Ibuprofen (Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively.
M3936	Saikosaponin D	Saikosaponin D is a COX-2 and iNOS inhibitor,a Saikosaponin A epimer, which Inhibits NF-κB, TNF-α, IL-1β and IL-6 and Inhibits apoptosis.
M1965	Celecoxib	Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor (IC50 values are 15 and 0.04 μM for COX-1 and COX-2 respectively).
M3471	Ketorolac	Ketorolac (Ketorolac tromethamine) is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively.
M20423	Etoricoxib	Etoricoxib is a new COX-2 selective inhibitor with anti-inflammatory, antipyretic, analgesic, and potential antineoplastic properties.
M2824	Lumiracoxib	Lumiracoxib is a novel, selective COX-2 inhibitor with IC50 and K_i of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1.
M2233	Nepafenac	Nepafenac is an analgesic selective inhibitor of COX-2.
M1830	Firocoxib	Firocoxib is a selective COX-2 inhibitor exhibiting high selectivity to inhibit COX-2.
M54842	Oxyphenbutazone	Oxyphenbutazone is an orally active non-selective COX inhibitor. Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis.
M45278	Birch triterpenes	Birch triterpenes is a cyclooxygenase-2 (COX-2) inhibitor that can be used in studies related to epidermolysis bullosa.
M45105	Naproxcinod	Naproxcinod is a first-of-its-kind (first-in-class) cyclooxygenase-inhibiting nitric oxide donors (CINODs) with analgesic and anti-inflammatory activity for studies related to osteoarthritis and inflammation.
M44870	Hamaudol	Hamaudol is a chromone isolated from Saposhnikovia divaricata.
M41976	PYZ18	PYZ18 is a selective COX-2 inhibitor with an IC50 of 7.07 μM.
M41975	BW 755C	BW 755C is a 5-lipoxygenase (5-LO) inhibitor with an IC50 of 5 μM.
M41974	AHR-10037	AHR-10037 is a non-steroidal anti-inflammatory agent with low gastric toxicity.
M41973	Esculentic acid	Esculentic acid is a selective COX-2 inhibitor and has anti-inflammatory effect.
M41972	COX-2-IN-34	COX-2-IN-34 is a selective and orally active inhibitor of COX-2 , with an IC50 of 0.42 μM.
M41971	COX-1/2-IN-5	COX-1/2-IN-5 is a dual inhibitor of COX1/2 (IC50=2.650 μM, 0.958 μM), with anticancer activity.
M41970	COX-2-IN-33	COX-2-IN-33 is a COX-2 inhibitor (IC50=45.5 nM), as well as a potential anti-inflammatory agent.
M41969	COX-2-IN-31	COX-2-IN-31 is an orally active and dual inhibitor of COX-2 (IC50=60 nM) and 5-LOX (IC50=1.9 μM).
M41968	Axinelline A	Axinelline A is a potent COX inhibitor with IC50s of 2.22 μM and 8.89 μM against COX-2 and COX-1, respectively.
M41967	2-O-Sinapoyl makisterone A	2-O-Sinapoyl makisterone A, a sinapinic acid-ecdysterone hybrid, is a selective inhibitor of COX-2.
M41966	COX-1/2-IN-4	COX-1/2-IN-4 is anCOX inhibitorwith IC50 values of 0.239 μM and 0.191 μM for COX-1 enzyme and COX-2 enzyme , respectively.
M41965	COX-2-IN-30	COX-2-IN-30 is a benzenesulfonamide derivative, as well as an orally active and dual inhibitor of COX (IC50=49 nM for COX-2, 10.4 μM for COX-1) and 5-LOX (IC50=2.4 μM).
M38974	Acetaminophen-d3	Acetaminophen-d3 is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.
M38973	(S)-Flurbiprofen	(S)-Flurbiprofen is an active enantiomer of Flurbiprofen, with IC50 values of 0.48 μM and 0.47 μM for COX-1 and COX-2, respectively.

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COX Cyclooxygenase

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