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Ketorolac tromethamine salt (RS37619 tromethamine salt) is a non-selective COX inhibitor with IC50 of 31.5 µM and 60.5 µM for human recombinant COX-1 and COX-2, respectively. Ketorolac tromethamine is a non-steroidal anti-inflammatory agent (NSAID) in the family of heterocyclic acetic acid derivative, often used as an analgesic, antipyretic (fever reducer), and anti-inflammatory. Ketorolac tromethamine (Toradol) acts by inhibiting the bodily synthesis of prostaglandins. The primary mechanism of action responsible for ketorolac’s anti-inflammatory, antipyretic and analgesic effects is the inhibition of prostaglandin synthesis by competitive blocking of the enzyme cyclooxygenase (COX).
MedComm (2020). 2023 Sep 20;4(5):e363.
Arachidonic acid metabolism in health and disease
Ketorolac tromethamine salt purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | Primary human osteoblasts cell lines |
| Preparation method | Exposing human osteoblasts cells to Ketorolac for 24 hours.Assessing thymidine incorporation by the TopCount Microplate Scintillation and Luminescence Counters through adding [3H]-thymidine to cultures 4 hours prior to harvesting. Using propidium iodide in flow cytometer to determine cell cycle distribution , and using the Annexin V-FITC Apoptosis Detection Kit to detect cell apoptosis or necrosis. |
| Concentrations | Dissolved in DMSO, final concentration ~0.1 mM |
| Incubation time | 24 hours |
| Animal Experiment | |
|---|---|
| Animal models | Male Wistar rats |
| Formulation | Dissolved in DMSO and diluted in saline. |
| Dosages | 0.3-30 mg/kg |
| Administration | Take orally |
| Molecular Weight | 376.4 |
| Formula | C19H24N2O6 |
| CAS Number | 74103-07-4 |
| Solubility (25°C) | Water 90 mg/mL DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Ewan D McNicol, et al. Ketorolac for postoperative pain in children
[3] Benjamin Maslin, et al. Safety Considerations in the Use of Ketorolac for Postoperative Pain
| Related COX Products |
|---|
| Sudoxicam
Sudoxicam is a reversible and orally active COX antagonist and a non-steroidal anti-inflammatory agent from the enol-carboxamide class. |
| Metyrosine
Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine significantly inhibits high COX-2 activity. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. |
| PPOH
PPOH, a fatty acid derivative, is a selective cyclooxygenase (COX) inhibitor that inhibits arachidonic acid cyclooxygenase activity in renal cortical microsomes. |
| Tenidap
Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 μM and 1.2 μM for COX-1 and COX-2, respectively. |
| COX-2-IN-6
COX-2-IN-6 is an orally active, gut-restricted and selective cyclooxygenase-2 (COX-2) inhibitor for colorectal Chemoprevention of cancer. |
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