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COX Cyclooxygenase

Cat.No.  Name Information
M3264 Pravadoline Pravadoline (WIN 48098) is a cyclooxygesase inhibitor and inhibits prostaglandin synthesis with IC50 of 4.9 μM, also a cannabinoid agonist.
M2495 Carprofen Carprofen inhibits canine COX2 with IC50 of 0.03 mM.
M3359 Ibuprofen Ibuprofen (Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively.
M3936 Saikosaponin D Saikosaponin D is a COX-2 and iNOS inhibitor,a Saikosaponin A epimer, which Inhibits NF-κB, TNF-α, IL-1β and IL-6 and Inhibits apoptosis.
M1965 Celecoxib Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor (IC50 values are 15 and 0.04 μM for COX-1 and COX-2 respectively).
M3471 Ketorolac Ketorolac (Ketorolac tromethamine) is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively.
M20423 Etoricoxib Etoricoxib is a new COX-2 selective inhibitor with anti-inflammatory, antipyretic, analgesic, and potential antineoplastic properties.
M2824 Lumiracoxib Lumiracoxib is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1.
M5703 Iguratimod Iguratimod(T-614) is a selective inhibitor of cyclo-oxygenase-2 (COX-2), and inhibits the production of interleukin-1 (IL-1), IL-6, IL-8 and tumour necrosis factor.
M5677 Psoralidin Psoralidin, a natural furanocoumarin, is isolated from Psoralea corylifolia L. possessing anti-cancer properties.
M5658 Flurbiprofen Flurbiprofen is a phenylalkanic acid derivative, which is a non-steroidal anti-inflammatory compound (NSAIDs).
M5655 Flunixin Meglumin Flunixin Meglumin is a potent inhibitor of the enzyme cyclooxygenase used as analgesic agent with anti-inflammatory and antipyretic activity.
M5643 Fenoprofen Calcium hydrate Fenoprofen calcium hydrate is a non-steroidal anti-inflammatory drug (NSAID).
M5639 Fenbufen Fenbufen is an orally active phenylalkanoic derivative with anti-inflammatory, analgesic and antipyretic activity. It is a non-steroidal anti-inflammatory drug.
M5634 Etodolac Etodolac is a nonsteroidal anti-inflammatory drug (NSAID) and a COX inhibitor, used for the treatment of inflammation and pain.
M5574 Diflunisal Diflunisal is a difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic and anti-inflammatory properties. The mechanism of action of diflunisal is as a Cyclooxygenase Inhibitor.
M5572 Diclofenac Diclofenac (diclofenac) is a COX inhibitor and has an IC50 of 60 and 220 nM for sheep COX-1 and -2, respectively.
M5381 Acemetacin Acemetacin is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.
M5379 Aceclofenac Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac.
M5366 4-Aminoantipyrine 4-Aminoantipyrine(Ampyrone) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties.
M5361 2-Ethoxybenzamide 2-ethoxybenzamide is a common analgesic and anti-inflammatory compound used to relieve fever, fever, headache and other mild pain.
M5352 (R)-(-)-Ibuprofen (R)-Ibuprofen, a nonsteroidal anti-inflammatory, is the less active enantiomer of ibuprofen, an inhibitor of Cox-1 and Cox-2.
M5351 (+/-)-Sulfinpyrazone Sulfinpyrazone is one of the most studied platelet COX inhibitors, also a uricosuric agent that competitively inhibits uric acid reabsorption in kidney proximal tubules.
M5185 Xanthohumol Xanthohumol is an inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).
M4761 Avicularin Avicularin is a bioactive flavonoid found in a variety of plants. It has anti-inflammatory, anti-allergy, anti-oxidation, liver protection, anti-tumor and other effects. Avicularin inhibits NF-κB (p65), COX-2 and PPAR-γ activities. In LPS-stimulated RAW 264.7 macrophages, Avicularin produces anti-inflammatory activity by inhibiting the ERK signaling pathway.
M4673 Esculentoside-A Esculentoside A (EsA), A triterpenoid saponin isolated from the root of Phytolacca esculenta.
M4667 Homoorientin Homoorientin (Isoorientin) is a potent inhibitor of COX-2 with an IC50 value of 39 μM.
M4655 Byakangelicol Byakangelicol is white triol separated from Angelica dahurica, Interleukin-1 β (IL-1β) -induced release of prostaglandin E2 (PGE2) in A549 cells was inhibited by inhibiting the expression and activity of coX-2. Byakangelicol can be used to study airway inflammation.




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