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Acemetacin

Cat. No. M5381
Acemetacin Structure
Size Price Availability Quantity
50mg USD 70  USD70 In stock
200mg USD 200  USD200 In stock
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Quality Control & Documentation
Biological Activity

Acemetacin is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.

Chemical Information
Molecular Weight 415.82
Formula C21H18ClNO6
CAS Number 53164-05-9
Solubility (25°C) 83 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sanphui P, et al. IUCrJ. Acemetacin cocrystals and salts: structure solution from powder X-ray data and form selection of the piperazine salt.

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