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Diflunisal

Cat. No. M5574
Diflunisal Structure
Synonym:

Dolobid, Dolobis, Flovacil, Fluniget

Size Price Availability Quantity
100mg USD 85  USD85 In stock
500mg USD 250  USD250 In stock
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Quality Control & Documentation
Biological Activity

Diflunisal is a difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic and anti-inflammatory properties. The mechanism of action of diflunisal is as a Cyclooxygenase Inhibitor.

Chemical Information
Molecular Weight 250.20
Formula C13H8F2O3
CAS Number 22494-42-4
Solubility (25°C) 50 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sekijima Y, et al. Amyloid. Safety and efficacy of long-term diflunisal administration in hereditary transthyretin (ATTR) amyloidosis.

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Keywords: Diflunisal, Dolobid, Dolobis, Flovacil, Fluniget supplier, COX, inhibitors, activators


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