| Cat.No. | Name | Information |
|---|---|---|
| M3264 | Pravadoline | Pravadoline (WIN 48098) is a cyclooxygesase inhibitor and inhibits prostaglandin synthesis with IC50 of 4.9 μM, also a cannabinoid agonist. |
| M2495 | Carprofen | Carprofen inhibits canine COX2 with IC50 of 0.03 mM. |
| M3359 | Ibuprofen | Ibuprofen (Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively. |
| M3936 | Saikosaponin D | Saikosaponin D is a COX-2 and iNOS inhibitor,a Saikosaponin A epimer, which Inhibits NF-κB, TNF-α, IL-1β and IL-6 and Inhibits apoptosis. |
| M3466 | Indomethacin | Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin can be used for cancer, inflammation and viral infection research. |
| M1965 | Celecoxib | Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor (IC50 values are 15 and 0.04 μM for COX-1 and COX-2 respectively). |
| M3471 | Ketorolac tromethamine salt | Ketorolac tromethamine salt (Ketorolac tromethamine) is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively. |
| M20423 | Etoricoxib | Etoricoxib is a new COX-2 selective inhibitor with anti-inflammatory, antipyretic, analgesic, and potential antineoplastic properties. |
| M2824 | Lumiracoxib | Lumiracoxib is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. |
| M3915 | Catechin | Catechin (Cianidanol) is a flavan-3-ol, a type of natural phenol and antioxidant. Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. |
| M45278 | Birch triterpenes | Birch triterpenes is a cyclooxygenase-2 (COX-2) inhibitor that can be used in studies related to epidermolysis bullosa. |
| M45105 | Naproxcinod | Naproxcinod is a first-of-its-kind (first-in-class) cyclooxygenase-inhibiting nitric oxide donors (CINODs) with analgesic and anti-inflammatory activity for studies related to osteoarthritis and inflammation. |
| M41976 | PYZ18 | PYZ18 is a selective COX-2 inhibitor with an IC50 of 7.07 μM. |
| M41975 | BW 755C | BW 755C is a 5-lipoxygenase (5-LO) inhibitor with an IC50 of 5 μM. |
| M41974 | AHR-10037 | AHR-10037 is a non-steroidal anti-inflammatory agent with low gastric toxicity. |
| M41973 | Esculentic acid | Esculentic acid is a selective COX-2 inhibitor and has anti-inflammatory effect. |
| M41972 | COX-2-IN-34 | COX-2-IN-34 is a selective and orally active inhibitor of COX-2 , with an IC50 of 0.42 μM. |
| M41971 | COX-1/2-IN-5 | COX-1/2-IN-5 is a dual inhibitor of COX1/2 (IC50=2.650 μM, 0.958 μM), with anticancer activity. |
| M41970 | COX-2-IN-33 | COX-2-IN-33 is a COX-2 inhibitor (IC50=45.5 nM), as well as a potential anti-inflammatory agent. |
| M41969 | COX-2-IN-31 | COX-2-IN-31 is an orally active and dual inhibitor of COX-2 (IC50=60 nM) and 5-LOX (IC50=1.9 μM). |
| M41968 | Axinelline A | Axinelline A is a potent COX inhibitor with IC50s of 2.22 μM and 8.89 μM against COX-2 and COX-1, respectively. |
| M41967 | 2-O-Sinapoyl makisterone A | 2-O-Sinapoyl makisterone A, a sinapinic acid-ecdysterone hybrid, is a selective inhibitor of COX-2. |
| M41966 | COX-1/2-IN-4 | COX-1/2-IN-4 is anCOX inhibitorwith IC50 values of 0.239 μM and 0.191 μM for COX-1 enzyme and COX-2 enzyme , respectively. |
| M41965 | COX-2-IN-30 | COX-2-IN-30 is a benzenesulfonamide derivative, as well as an orally active and dual inhibitor of COX (IC50=49 nM for COX-2, 10.4 μM for COX-1) and 5-LOX (IC50=2.4 μM). |
| M38974 | Acetaminophen-d3 | Acetaminophen-d3 is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor. |
| M38973 | (S)-Flurbiprofen | (S)-Flurbiprofen is an active enantiomer of Flurbiprofen, with IC50 values of 0.48 μM and 0.47 μM for COX-1 and COX-2, respectively. |
| M38972 | 3,9-Dihydroeucomin | 3,9-Dihydroeucomin (compound 12) is a natural homoisoflavonoid compound with less COX-2 inhibitory activitys. |
| M38971 | Phenethyl ferulate | Phenethyl ferulate is a major constituent ofQianghuo, shows inhibitory activity against cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) with IC50 values of 4.35 μM and 5.75 μM, respectively. |
| M30710 | Indomethacin farnesil | Indomethacin farnesil is an orally active proagent of Indomethacin. Indomethacin (Indometacin) is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes. |
| M30613 | Mofezolac | Mofezolac, a non-steroidal anti-inflammatory drug (NSAID), is a selective, reversible and orally active COX-1 inhibitor with an IC50 of 1.44 nM. Mofezolac shows weak inhibitory activity on COX-2 (IC50 of 447 nM). Mofezolac can relieve pain and has anti-inflammatory activities. |
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