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Lornoxicam

Cat. No. M3203
Lornoxicam Structure
Synonym:

Chlortenoxicam

Size Price Availability Quantity
100mg USD 90  USD90 In stock
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Quality Control & Documentation
Biological Activity

Lornoxicam is a COX-1 and COX-2 inhibitor with IC50 of 5 nM and 8 nM, respectively.

Chemical Information
Molecular Weight 371.82
Formula C13H10ClN3O4S2
CAS Number 70374-39-9
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jamal Hussen, et al. Immunomodulatory Effects of the Cyclooxygenase Inhibitor Lornoxicam on Phenotype and Function of Camel Blood Leukocytes

[2] Vicky Karakitsou, et al. Presumptive Lornoxicam Intoxication in Four Dogs

[3] Christian Hillstrom, et al. Lornoxicam : pharmacology and usefulness to treat acute postoperative and musculoskeletal pain a narrative review

[4] Mahrous O Ahmed, et al. Lornoxicam

[5] N M Skjodt, et al. Clinical pharmacokinetics of lornoxicam. A short half-life oxicam

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Keywords: Lornoxicam, Chlortenoxicam supplier, COX, inhibitors, activators


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