Free shipping on all orders over $ 500

Naproxen sodium

Cat. No. M3608
Naproxen sodium Structure
Size Price Availability Quantity
100mg USD 30  USD30 In stock
500mg USD 50  USD50 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Naproxen (Aleve) is a non-selective cyclooxygenase (COX) inhibitor with IC50 of 8.7 ?0.23 mg/kg. It displays anti-inflammatory, antipyretic and analgesic effects and has a neuroprotective role against colchicine-induced cognitive impairment and oxidative stress.

Chemical Information
Molecular Weight 252.24
Formula C14H13NaO3
CAS Number 26159-34-2
Solubility (25°C) Water 70 mg/mL
Ethanol 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Nizar Al-Zoubi, et al. Spray drying of naproxen and naproxen sodium for improved tableting and dissolution - physicochemical characterization and compression performance

[2] Yahiya Y Syed. Sumatriptan/Naproxen Sodium: A Review in Migraine

[3] Lily P H Yang. Sumatriptan/naproxen sodium: a review of its use in adult patients with migraine

[4] Catalina Cleves, et al. Sumatriptan/naproxen sodium combination for the treatment of migraine

[5] L B Sutton. Naproxen sodium

Related COX Products
Birch triterpenes

Birch triterpenes is a cyclooxygenase-2 (COX-2) inhibitor that can be used in studies related to epidermolysis bullosa.

Naproxcinod

Naproxcinod is a first-of-its-kind (first-in-class) cyclooxygenase-inhibiting nitric oxide donors (CINODs) with analgesic and anti-inflammatory activity for studies related to osteoarthritis and inflammation.

Hamaudol

Hamaudol is a chromone isolated from Saposhnikovia divaricata.

(±)-Catechin

(±)-Catechin (rel-Cianidanol) is the racemate of Catechin.

PYZ18

PYZ18 is a selective COX-2 inhibitor with an IC50 of 7.07 μM.

  Catalog
Abmole Inhibitor Catalog




Keywords: Naproxen sodium supplier, COX, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.