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Nimesulide

Cat. No. M3398
Nimesulide Structure
Synonym:

R805

Size Price Availability Quantity
200mg USD 80  USD80 In stock
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Quality Control & Documentation
Biological Activity

Nimesulide is a relatively COX-2 selective inhibitor with IC50 of 26 μM.

Chemical Information
Molecular Weight 308.31
Formula C13H12N2O5S
CAS Number 51803-78-2
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Elisabetta Caiazzo, et al. The relatively selective cyclooxygenase-2 inhibitor nimesulide: What's going on?

[2] Jeongyoon Kwon, et al. Nimesulide-induced hepatotoxicity: A systematic review and meta-analysis

[3] C Mattia, et al. Nimesulide: 25 years later

[4] V G Barskova, et al. Nimesulide

[5] M Pulkkinen. Nimesulide in dysmenorrhoea

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  Catalog
Abmole Inhibitor Catalog




Keywords: Nimesulide, R805 supplier, COX, inhibitors, activators


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