Free shipping on all orders over $ 500

Zaltoprofen

Cat. No. M3360
Zaltoprofen Structure
Synonym:

CN100

Size Price Availability Quantity
10mg USD 70  USD70 In stock
50mg USD 120  USD120 In stock
100mg USD 180  USD180 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Zaltoprofen is an orally active COX inhibitor with IC50 values of 1.3 and 0.34 μM for COX-1 and COX-2, respectively, and possesses potent anti-inflammatory activity.

Chemical Information
Molecular Weight 298.36
Formula C17H14O3S
CAS Number 74711-43-6
Solubility (25°C) DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Giovanna Bruni, et al. Zaltoprofen/4,4'-Bipyridine: A Case Study to Demonstrate the Potential of Differential Scanning Calorimetry (DSC) in the Pharmaceutical Field

[2] Lin Jia, et al. Chirality Influence of Zaltoprofen Towards UDP-Glucuronosyltransferases (UGTs) Inhibition Potential

[3] Ig Jun Cho, et al. Differential anti-inflammatory and analgesic effects by enantiomers of zaltoprofen in rodents

[4] Tatsuro Kohno. Zaltoprofen inhibits bradykinin-mediated enhancement of glutamate receptor activity in substantia gelatinosa neurons

[5] Toshihiro Okamoto. NSAID zaltoprofen improves the decrease in body weight in rodent sickness behavior models: proposed new applications of NSAIDs (Review)

Related COX Products
Birch triterpenes

Birch triterpenes is a cyclooxygenase-2 (COX-2) inhibitor that can be used in studies related to epidermolysis bullosa.

Naproxcinod

Naproxcinod is a first-of-its-kind (first-in-class) cyclooxygenase-inhibiting nitric oxide donors (CINODs) with analgesic and anti-inflammatory activity for studies related to osteoarthritis and inflammation.

Hamaudol

Hamaudol is a chromone isolated from Saposhnikovia divaricata.

(±)-Catechin

(±)-Catechin (rel-Cianidanol) is the racemate of Catechin.

PYZ18

PYZ18 is a selective COX-2 inhibitor with an IC50 of 7.07 μM.

  Catalog
Abmole Inhibitor Catalog




Keywords: Zaltoprofen, CN100 supplier, COX, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.