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Piroxicam

Cat. No. M3429
Piroxicam Structure
Size Price Availability Quantity
1g USD 50  USD50 In stock
5g USD 115  USD115 In stock
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Quality Control & Documentation
Biological Activity

Piroxicam (Feldene) is a non-selective COX inhibitor with an IC50 of 6 mM. It is a non-steroidal anti-inflammatory compound used to relieve the symptoms of rheumatoid and osteoarthritis, primary dysmenorrhoea, postoperative pain; and acts as an analgesic, especially where there is an inflammatory component.

Chemical Information
Molecular Weight 331.35
Formula C15H13N3O4S
CAS Number 36322-90-4
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Marta Gallo, et al. Piroxicam Loading onto Mesoporous Silicas by Supercritical CO 2 Impregnation

[2] Gamal A E Mostafa, et al. Piroxicam

[3] Saganuwan A Saganuwan. In vivo Piroxicam Metabolites: Possible Source for Synthesis of Central Nervous System (CNS) Acting Depressants

[4] Saganuwan Alhaji Saganuwan. Piroxicam: Source for Synthesis of Central Nervous System (CNS) Acting Drugs

[5] A Calin. Therapeutic focus. Piroxicam

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  Catalog
Abmole Inhibitor Catalog




Keywords: Piroxicam supplier, COX, inhibitors, activators


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