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Asaraldehyde

Cat. No. M3308
Asaraldehyde Structure
Synonym:

Asaronaldehyde

Size Price Availability Quantity
50mg USD 120  USD120 In stock
200mg USD 300  USD300 In stock
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Quality Control & Documentation
Biological Activity

Asaraldehyde (Asaronaldehyde) is a selective COX-2 inhibitor. Asaraldehyde (Asaronaldehyde) was found to be the most abundant constituent, but was totally absent in its cultured broth and its natural host, C. kanehirae wood. On feeding with the acid-digested sawdust of C. kanehirae wood or vanillin to the broth for culture, asaraldehyde (Asaronaldehyde) was produced in both cultured broths. Asaraldehyde (Asaronaldehyde) showed 3.32% of prostaglandin H endoperoxide synthase-1 (COX-1) inhibitory activity and 52.69% prostaglandin H endoperoxide synthase-2 (COX-2) inhibitory activity, respectively at 100 mg/ml. 2,4,5-trimethoxybenzaldehyde showed selectivity towards COX-2 enzyme inhibition at 100 ug/ml. The COX-2/COX-1 ratio for compound 1 was 17.68 at 100 ug/ml compared to solvent control.

Protocol (for reference only)
Cell Experiment
Cell lines 3T3-L1 cells
Preparation method Seeding 3T3-L1 cells in 96-well plates at a concentration of 104 /well. Twenty-four hours later, treating the cells with 100 μg/mL of Asaraldehyde for 24 hours or for the whole 8-day differentiation period. Also, testing fully differentiated adipocytes with 100 μg/mL of Asaraldehyde for 24 hours-72 hours to test the cytotoxicity. Culturing cells with MTT at a final concentration of 0.5 mg/mL for another 4 hours at the end of treatment. The purple MTT formazan is dissolved by DMSO and the absorbance at 570 nm is taken with a spectrophotometer. The absorbance is proportional to the viability of adipocytes
Concentrations 100 μg/mL
Incubation time 24 hours
Animal Experiment
Animal models
Formulation
Dosages
Administration
Chemical Information
Molecular Weight 196.2
Formula C10H12O4
CAS Number 4460-86-0
Solubility (25°C) DMSO 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jian Zou, et al. Biotransformation of α-asarone by Alternaria longipes CGMCC 3.2875

[2] Zhao-Jie Wang, et al. Bioguided isolation, identification and activity evaluation of antifungal compounds from Acorus tatarinowii Schott

[3] Cheol Hyeong Park, et al. Phenolic constituents of Acorus gramineus

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Keywords: Asaraldehyde, Asaronaldehyde supplier, COX, inhibitors, activators


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