Xanthohumol is an inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).
Molecular Weight | 354.4 |
Formula | C21H22O5 |
CAS Number | 6754-58-1 |
Solubility (25°C) | DMSO 72 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Sosmitha Girisa, et al. Xanthohumol from Hop: Hope for cancer prevention and treatment
[4] Hardeep S Tuli, et al. Xanthohumol: A Metabolite with Promising Anti-Neoplastic Potential
Related COX Products |
---|
Birch triterpenes
Birch triterpenes is a cyclooxygenase-2 (COX-2) inhibitor that can be used in studies related to epidermolysis bullosa. |
Naproxcinod
Naproxcinod is a first-of-its-kind (first-in-class) cyclooxygenase-inhibiting nitric oxide donors (CINODs) with analgesic and anti-inflammatory activity for studies related to osteoarthritis and inflammation. |
Hamaudol
Hamaudol is a chromone isolated from Saposhnikovia divaricata. |
(±)-Catechin
(±)-Catechin (rel-Cianidanol) is the racemate of Catechin. |
PYZ18
PYZ18 is a selective COX-2 inhibitor with an IC50 of 7.07 μM. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.