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Homoorientin (Isoorientin) is a potent inhibitor of COX-2 with an IC50 value of 39 μM.
 |
Source | Onco Targets Ther (2016). Figure 3. Homoori-entin |
| Method | Apoptosis assay | |
| Cell Lines | PANC-1 and PATU-8988 cells | |
| Concentrations | 20, 40, 80, and 160 μM | |
| Incubation Time | 24 h | |
| Results | The isoorientin-induced apoptotic response was increased in the normal PC group |
 |
Source | Onco Targets Ther (2016). Figure 2. Homoori-entin |
| Method | immunoblots | |
| Cell Lines | PANC -1 cell lines | |
| Concentrations | 20, 40, 80, and 160 μM | |
| Incubation Time | 24 h | |
| Results | The cell proliferation in the isoorientin-treated group was not significantly different from that in the untreated group in both the PANC-1 and PATU-8988 cell lines |
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | Male Sprague-Dawley rats |
| Formulation | 2% tween 80–98% physiologic saline |
| Dosages | 5, 10, and 15 mg/kg |
| Administration | i.v. |
| Molecular Weight | 448.38 |
| Formula | C21H20O11 |
| CAS Number | 4261-42-1 |
| Form | Solid |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related COX Products |
|---|
| Sudoxicam
Sudoxicam is a reversible and orally active COX antagonist and a non-steroidal anti-inflammatory agent from the enol-carboxamide class. |
| Metyrosine
Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine significantly inhibits high COX-2 activity. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. |
| PPOH
PPOH, a fatty acid derivative, is a selective cyclooxygenase (COX) inhibitor that inhibits arachidonic acid cyclooxygenase activity in renal cortical microsomes. |
| Tenidap
Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 μM and 1.2 μM for COX-1 and COX-2, respectively. |
| COX-2-IN-6
COX-2-IN-6 is an orally active, gut-restricted and selective cyclooxygenase-2 (COX-2) inhibitor for colorectal Chemoprevention of cancer. |
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