Homoorientin (Isoorientin) is a potent inhibitor of COX-2 with an IC50 value of 39 μM.
 |
Source | Onco Targets Ther (2016). Figure 3. Homoori-entin |
| Method | Apoptosis assay | |
| Cell Lines | PANC-1 and PATU-8988 cells | |
| Concentrations | 20, 40, 80, and 160 μM | |
| Incubation Time | 24 h | |
| Results | The isoorientin-induced apoptotic response was increased in the normal PC group |
 |
Source | Onco Targets Ther (2016). Figure 2. Homoori-entin |
| Method | immunoblots | |
| Cell Lines | PANC -1 cell lines | |
| Concentrations | 20, 40, 80, and 160 μM | |
| Incubation Time | 24 h | |
| Results | The cell proliferation in the isoorientin-treated group was not significantly different from that in the untreated group in both the PANC-1 and PATU-8988 cell lines |
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | Male Sprague-Dawley rats |
| Formulation | 2% tween 80–98% physiologic saline |
| Dosages | 5, 10, and 15 mg/kg |
| Administration | i.v. |
| Molecular Weight | 448.38 |
| Formula | C21H20O11 |
| CAS Number | 4261-42-1 |
| Form | Solid |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related COX Products |
|---|
| Oxyphenbutazone
Oxyphenbutazone is an orally active non-selective COX inhibitor. Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis. |
| Birch triterpenes
Birch triterpenes is a cyclooxygenase-2 (COX-2) inhibitor that can be used in studies related to epidermolysis bullosa. |
| Naproxcinod
Naproxcinod is a first-of-its-kind (first-in-class) cyclooxygenase-inhibiting nitric oxide donors (CINODs) with analgesic and anti-inflammatory activity for studies related to osteoarthritis and inflammation. |
| Hamaudol
Hamaudol is a chromone isolated from Saposhnikovia divaricata. |
| (±)-Catechin
(±)-Catechin (rel-Cianidanol) is the racemate of Catechin. |
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