γ-Tocopherol (D-γ-Tocopherol) is a potent cyclooxygenase (COX) inhibitor. γ-Tocopherol is a naturally occurring form of Vitamin E in many plant seeds, such as corn oil and soybeans. γ-Tocopherol possesses antiinflammatory properties and anti-cancer activity.
Molecular Weight | 416.68 |
Formula | C28H48O2 |
CAS Number | 54-28-4 |
Form | Liquid |
Solubility (25°C) | DMSO 100 mg/mL (ultrasonic) |
Storage | 4°C, protect from light |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Annette Abraham, et al. Crit Rev Food Sci Nutr. Vitamin E and its anticancer effects
[3] Karl-Heinz Wagner, et al. Ann Nutr Metab. Gamma-tocopherol--an underestimated vitamin?
[4] Sridevi Devaraj, et al. Am J Clin Nutr. Gamma-tocopherol, the new vitamin E?
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