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Cat. No. M6804
IBMX Structure

IMX; Isobutylmethylxanthine; Methylisobutylxanthine; NSC165960; SC2964

Size Price Availability Quantity
10mM*1mL USD 58.5  USD65 In stock
50mg USD 58.5  USD65 In stock
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Quality Control
Biological Activity

IBMX is a phosphodiesterase inhibitor (IC50 values are 13, 18, 19, 32 and 50 μM for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively). IBMX suppresses α-adrenoceptor-mediated 5-HT release from neuroendocrine epithelial cells (IC50 = 1.3 μM). IBMX (100 μM) activates renal outer medullary K+ (ROMK) channels (n=6, P<0.05) and prevents further channel activation by ANG II (n=6, P=NS) or cGMP.

Treatments with IBMX and Apocynin significantly decrease cold-induced elevation of right ventricular (RV) systolic pressure (23.5±1.8 and 24.2±0.6 mmHg, respectively) although they do not decrease RV pressure to the warm control levels. IBMX or Apocynin significantly reduces medial layer thickness (19.0±0.9, and 16.9±0.8 μm, respectively) and increases lumen diameter (62.7±4.2, and 59.5±4.3 μm, respectively) of small PAs in cold-exposed rats.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 222.24
Formula C10H14N4O2
CAS Number 28822-58-4
Purity 99.75%
Solubility DMSO: ≥ 32 mg/mL
Storage at -20°C

The phosphodiesterase inhibitor isobutylmethylxanthine attenuates behavioral sensitization to cocaine.
Schroeder JA, et al. Behav Pharmacol. 2012 Jun;23(3):310-4. PMID: 22495185.

KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channels.
Wu BN, et al. Br J Pharmacol. 2004 Aug;142(7):1105-14. PMID: 15237094.

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Keywords: IBMX, IMX; Isobutylmethylxanthine; Methylisobutylxanthine; NSC165960; SC2964 supplier, PDE, inhibitors

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