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AN2728

Cat. No. M2337
AN2728 Structure
Synonym:

Crisaborole

Size Price Availability Quantity
5mg USD 27  USD30 In stock
10mg USD 39.6  USD44 In stock
100mg USD 81  USD90 In stock
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Quality Control
Biological Activity

AN2728 is a topical anti-inflammatory product candidate for the treatment of psoriasis and atopic dermatitis. AN2728 inhibits PDE4 and reduces the production of TNF-alpha, a precursor of the inflammation associated with psoriasis as well as other cytokines, including IL-12 and IL-23, which are proteins believed to be involved in the inflammation process and immune responses. AN2728 is currently in Phase 2b for psoriasis and Phase 2 for atopic dermatitis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 251.04
Formula C14H10BNO3
CAS Number 906673-24-3
Purity 100.00%
Solubility DMSO 27 mg/mL
Storage at -20°C
References

AN-2728, a PDE4 inhibitor for the potential topical treatment of psoriasis and atopic dermatitis.
Nazarian R, et al. Curr Opin Investig Drugs. 2009 Nov;10(11):1236-42. PMID: 19876791.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: AN2728, Crisaborole supplier, PDE, inhibitors

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