About 30 results found for searched term "PDE" (0.011 seconds)
Cat.No. | Name | Information |
---|---|---|
M1728 | GSK256066 | GSK256066 is a selective phosphodiesterase 4 (PDE4)inhibitor with an IC50 of 3.2 pM. *The compound is unstable in solutions, freshly prepared is recommended |
M1734 | BAY-60-7550 | BAY-60-7550 is a potent PDE2 inhibitor with IC50 values of 2.0 nM (bovine) and 4.7 nM (human). |
M1871 | Roflumilast | Roflumilast (trade names Daxas, Daliresp) is a novel and selective, long-acting inhibitor of phosphodiesterase 4 (PDE-4). |
M1906 | Piclamilast | Piclamilast (RP 73401) is a potent and selective inhibitor of phosphodiesterase (PDE) 4. |
M2030 | Apremilast | Apremilast is a novel, orally available small molecule inhibitor of PDE4 with IC50 of 74 nM. |
M2410 | Avanafil | Avanafil is a highly selective PDE5 inhibitor with IC50 of 5.2 nM, >121-fold selectivity over other PDEs. |
M2764 | Ibudilast | Ibudilast is a potent PDE4 inhibitor for PDE4A with IC50 of 54 nM. |
M3337 | Milrinone | Milrinone is a potent and selective phosphodiesterase 3 inhibitor with an IC50 of 0.42 μM for the inhibition of FIII PDE. |
M3375 | S-(+)-Rolipram | S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer. |
M3394 | Deltarasin | Deltarasin is a novel small molecule which inhibits the KRAS-PDEδ interaction and thus impairing oncogenic KRAS signalling. |
M3434 | Pimobendan | Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM. |
M3437 | Cilomilast | Cilomilast is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. |
M3447 | PF-2545920 | PF-2545920 is a potent and selective PDE10A inhibitor with IC50 of 0.37 nM, with >1000-fold selectivity over the PDE. |
M3473 | Tadalafil | Tadalafil is a PDE-5 inhibitor with IC50 of 1.8 nM. |
M3566 | Vardenafil hydrochloride Trihydrate | Vardenafil hydrochloride Trihydrate is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively. |
M4851 | TAK-063 | TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM. |
M5174 | Icariin | Icariin is a flavonol glycoside. Icariin inhibited PDE5 and PDE4 activity with IC50 of 432 nM and 73.50 μM, respectively. Icariin is also a PPARα activator. |
M5519 | Cilostazol | Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake. |
M5833 | Olprinone | Olprinone(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor. |
M5939 | Rolipram | A selective inhibitor of PDE4, Rolipram, inhibits immunopurified PDE4B and PDE4D activity with IC50 of 130 nM and 240 nM, respectively. It has anti-inflammatory activity. Rolipram also increased cAMP levels and activated PKA, which in turn increased proteasome activity and inhibited tau aggregation. |
M6042 | Udenafil | Udenafil(DA8159) is a PDE5 inhibitor used in urology to treat erectile dysfunction. |
M6048 | Vardenafil HCl | Vardenafil Hcl is a PDE5 inhibitor used for treating erectile dysfunction. |
M6153 | E6005 | RVT-501 (E6005) is a selective phosphodiesterase 4 (PDE4PDE4) inhibitor with an IC50 of 2.8 nM. |
M6493 | BC 11-38 | BC 11-38 is a selective PDE11 inhibitor. |
M6533 | BRL 50481 | BRL 50481 is a selective PDE7 inhibitor. |
M6560 | Carbazeran citrate | Carbazeran citrate is a aldehyde oxidase substrate; PDE inhibitor. |
M6574 | CDP 840 hydrochloride | CDP 840 hydrochloride is a potent and selective PDE4 inhibitor. |
M6581 | CGH 2466 dihydrochloride | CGH 2466 dihydrochloride is a a 1, A 2B and A 3 antagonist and inhibitor of p38 MAPK and PDE4. |
M6604 | Cilostamide | Cilostamide is a pDE3 inhibitor. |
M6701 | Eggmanone | Eggmanone is a potent and selective PDE4 inhibitor; suppresses hedgehog signaling. |
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