Catalog

PDE Phosphodiesterase

Inhibitors

Cat.No.	Name	Information
M10179	Vesnarinone	Vesnarinone is a cardiotonic agent, mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity.
M9882	Roflumilast N-oxide	Roflumilast N-oxide is a phosphodiesterase 4 inhibitor.
M9679	CP671305	CP671305 is a potent and selective, orally active inhibitor of phosphodiesterase-4-D with high activities.
M9347	ITI-214 phosphate	ITI-214 phosphate is an orally active, potent and selective inhibitors of PDE1, exhibits potent PDE1 inhibitory activity (Ki = 58 pM).
M6804	IBMX	IBMX is a pDE inhibitor (non-selective) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively.
M6287	GLPG1690	GLPG1690 (Ziritaxestat) is a first-in-class autotaxin (ATX) inhibitor, with IC50 of 131 nM and Ki of 15 nM.
M6153	E6005	RVT-501 (E6005) is a selective phosphodiesterase 4 (PDE4PDE4) inhibitor with an IC50 of 2.8 nM.
M6048	Vardenafil HCl	Vardenafil Hcl is a PDE5 inhibitor used for treating erectile dysfunction.
M6042	Udenafil	Udenafil(DA8159) is a PDE5 inhibitor used in urology to treat erectile dysfunction.
M6007	Theophylline	Theophylline is a methylated xanthine derivative; competitive nonselective phosphodiesterase inhibitor and nonselective adenosine receptor antagonist.
M5960	Sildenafil Mesylate	Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.
M5959	Sildenafil	Sildenafil is a Phosphodiesterase 5 Inhibitor with IC50 of 5.22 nM.
M5939	Rolipram	The PDE4 selective inhibitor, rolipram, inhibited immunopurified PDE4B and PDE4D activities similarly, with IC50 values of approx. 130 nM and 240 nM respectively; an anti-inflammatory agent.
M5519	Cilostazol	Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.
M4964	HA130	HA130 is a selective ATX (autotaxin) inhibitor with IC50 of 28 nM.
M4851	TAK-063	TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM.
M3588	Aminophylline	Aminophylline is a competitive nonselective phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nonselective adenosine receptor antagonist.
M3587	Dyphylline	Dyphylline is a xanthine derivative with bronchodilator and vasodilator effects.
M3566	Vardenafil hydrochloride Trihydrate	Vardenafil hydrochloride Trihydrate is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.
M3473	Tadalafil	Tadalafil is a PDE-5 inhibitor with IC50 of 1.8 nM.
M3447	PF-2545920	PF-2545920 is a potent and selective PDE10A inhibitor with IC50 of 0.37 nM, with >1000-fold selectivity over the PDE.
M3437	Cilomilast	Cilomilast is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity.
M3434	Pimobendan	Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM.
M3394	Deltarasin	Deltarasin is a novel small molecule which inhibits the KRAS-PDEδ interaction and thus impairing oncogenic KRAS signalling.
M3375	S-(+)-Rolipram	S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer.
M3337	Milrinone	Milrinone is a potent and selective phosphodiesterase 3 inhibitor with an IC50 of 0.42 μM for the inhibition of FIII PDE.
M3259	Irsogladine	Irsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.
M2764	Ibudilast	Ibudilast is a potent PDE4 inhibitor for PDE4A with IC50 of 54 nM.
M2410	Avanafil	Avanafil is a highly selective PDE5 inhibitor with IC50 of 5.2 nM, >121-fold selectivity over other PDEs.
M2395	Anagrelide hydrochloride	Anagrelide is a compound used for the treatment of essential thrombocytosis.
M2337	AN2728	AN2728 is a topical anti-inflammatory product candidate for the treatment of psoriasis and atopic dermatitis.
M2286	Sildenafil citrate	Sildenafil citrate is an agent used to treat erectile dysfunction and pulmonary arterial hypertension (PAH).
M2030	Apremilast	Apremilast is a novel, orally available small molecule inhibitor of PDE4 with IC50 of 74 nM.
M1906	Piclamilast	Piclamilast (RP 73401) is a potent and selective inhibitor of phosphodiesterase (PDE) 4.
M1871	Roflumilast	Roflumilast (trade names Daxas, Daliresp) is a novel and selective, long-acting inhibitor of phosphodiesterase 4 (PDE-4).
M1734	BAY-60-7550	BAY-60-7550 is a potent PDE2 inhibitor with IC50 values of 2.0 nM (bovine) and 4.7 nM (human).
M1728	GSK256066	GSK256066 is a selective phosphodiesterase 4 (PDE4)inhibitor with an IC50 of 3.2 pM.

Signaling Pathways

Product Type

PDE Phosphodiesterase

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