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PDE Phosphodiesterase

Cat.No.  Name Information
M6804 IBMX IBMX is a pDE inhibitor (non-selective) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively.
M2030 Apremilast Apremilast is a novel, orally available small molecule inhibitor of PDE4 with IC50 of 74 nM.
M49399 ATX inhibitor 1 ATX inhibitor 1 is a potent ATX (IC50=1.23 nM, FS-3; 2.18 nM, bis-pNPP) inhibitor.
M28851 Cudetaxestat Cudetaxestat (BLD-0409) is a potent and orally active autotaxin (ATX) inhibitor.
M25404 Nerandomilast (BI 1015550) Nerandomilast (BI 1015550) is a novel, orally active phosphodiesterase 4B (PDE4B) inhibitor (IC50 = 7.2 nM) with anti-fibrotic and anti-inflammatory effects.
M21175 BIO-32546 Compound BIO-32546 is a potent (IC50=1 nM), selective, orally administered, non-zinc-binding reversible inhibitor of autophagy (ATX).
M21149 FPFT-2216 FPFT-2216 is a ''molecular glue'' compound that degrades phosphatidiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3) and casein kinase 1α (CK1α). It can be used for cancer and inflammatory disease research.
M21089 Mirodenafil Mirodenafil is a newly developed oral type 5 phosphodiesterase inhibitor. mirodenafil is a modulator of the glucocorticoid receptor (GR). mirodenafil activates the Wnt/β-catenin signaling pathway by downregulating the expression of Dkk1. mirodenafil can be used to study erectile dysfunction (ED), Alzheimer's disease (AD) and systemic sclerosis (SSc). Mirodenafil can be used to study erectile dysfunction (ED), Alzheimer's disease (AD), and systemic sclerosis (SSc).
M20847 Ro 20-1724 Ro 20-1724 is a potent inhibitor of PDE IV with Ki value of 3.1 μM and a potent gastric secretagogues.
M14506 PF-04957325 PF-04957325 is a highly potent and selective PDE8 inhibitor, with IC50s of 0.7 nM and 0.3 nM for PDE8A and PDE8B, respectively.
M14505 PF-04447943 PF-04447943 is a potent inhibitor of human recombinant PDE9A (IC50=12 nM) with >78-fold selectivity, respectively, over other PDE family members (IC50>1000 nM).
M14499 (R)-(-)-Rolipram (R)-(-)-Rolipram is the R-enantiomer of Rolipram. Rolipram is a selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.
M11547 Ensifentrine Ensifentrine (RPL-554) is an inhaled, pioneering dual inhibitor of phosphodiesterase 3 (PDE3) and PDE4 with IC50 of 0.4 nM and 1479 nM, respectively. Ensifentrine has bronchoprotective and anti-inflammatory activity and can be used to study chronic obstructive pulmonary disease (COPD).
M11451 Autotaxin modulator 1 Autotaxin Modulator 1 is an Autotaxin (ATX) inhibitor of Autotaxin (ATX). Autotaxin Modulator 1 is expected to be used for demyelination caused by injury or disease, as well as for the study of proliferative diseases such as tumors.
M11109 3-O-Methylquercetin 3-O-Methylquercetin (3-MQ), a main constituent of Rhamnus nakaharai, inhibits total cAMP and cGMP-phosphodiesterase (PDE) of guinea pig trachealis. 3-O-Methylquercetin (3-MQ) exhibits IC50 values of 31.9 μM, 86.9 μM, 18.6 μM and 1.6 μM for PDE1, PDE5, PDE2 and PDE4, respectively.
M10631 Enpp-1-IN-1 Enpp-1-IN-1, also known as MV 658, is a Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1) inhibitor.
M10517 D159687 D159687 is a selective negative allosteric modulator (NAM) of PDE4D.
M10435 Difamilast Difamilast (OPA-15406) is a topical, highly selective and nonsteroidal phosphodiesterase-4 (PDE4) inhibitor.
M10179 Vesnarinone Vesnarinone is a cardiotonic agent, mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity.
M9882 Roflumilast N-oxide Roflumilast N-oxide is a phosphodiesterase 4 inhibitor.

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