Inhibitors
Cat.No. | Name | Information |
---|---|---|
M2030 | Apremilast | Apremilast is a novel, orally available small molecule inhibitor of PDE4 with IC50 of 74 nM. |
M11109 | 3-O-Methylquercetin | 3-O-Methylquercetin (3-MQ), a main constituent of Rhamnus nakaharai, inhibits total cAMP and cGMP-phosphodiesterase (PDE) of guinea pig trachealis. 3-O-Methylquercetin (3-MQ) exhibits IC50 values of 31.9 μM, 86.9 μM, 18.6 μM and 1.6 μM for PDE1, PDE5, PDE2 and PDE4, respectively. |
M10517 | D159687 | D159687 is a selective negative allosteric modulator (NAM) of PDE4D. |
M10435 | Difamilast | Difamilast (OPA-15406) is a topical, highly selective and nonsteroidal phosphodiesterase-4 (PDE4) inhibitor. |
M10179 | Vesnarinone | Vesnarinone is a cardiotonic agent, mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity. |
M9882 | Roflumilast N-oxide | Roflumilast N-oxide is a phosphodiesterase 4 inhibitor. |
M9679 | CP671305 | CP671305 is a potent and selective, orally active inhibitor of phosphodiesterase-4-D with high activities. |
M9347 | ITI-214 phosphate | ITI-214 phosphate is an orally active, potent and selective inhibitors of PDE1, exhibits potent PDE1 inhibitory activity (Ki = 58 pM). |
M6804 | IBMX | IBMX is a pDE inhibitor (non-selective) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively. |
M6287 | GLPG1690 | GLPG1690 (Ziritaxestat) is a first-in-class autotaxin (ATX) inhibitor, with IC50 of 131 nM and Ki of 15 nM. |
M6153 | E6005 | RVT-501 (E6005) is a selective phosphodiesterase 4 (PDE4PDE4) inhibitor with an IC50 of 2.8 nM. |
M6048 | Vardenafil HCl | Vardenafil Hcl is a PDE5 inhibitor used for treating erectile dysfunction. |
M6042 | Udenafil | Udenafil(DA8159) is a PDE5 inhibitor used in urology to treat erectile dysfunction. |
M6007 | Theophylline | Theophylline is a methylated xanthine derivative; competitive nonselective phosphodiesterase inhibitor and nonselective adenosine receptor antagonist. |
M5960 | Sildenafil Mesylate | Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5. |
M5959 | Sildenafil | Sildenafil is a Phosphodiesterase 5 Inhibitor with IC50 of 5.22 nM. |
M5939 | Rolipram | A selective inhibitor of PDE4, Rolipram, inhibits immunopurified PDE4B and PDE4D activity with IC50 of 130 nM and 240 nM, respectively. It has anti-inflammatory activity. Rolipram also increased cAMP levels and activated PKA, which in turn increased proteasome activity and inhibited tau aggregation. |
M5519 | Cilostazol | Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake. |
M4964 | HA130 | HA130 is a selective ATX (autotaxin) inhibitor with IC50 of 28 nM. |
M4851 | TAK-063 | TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM. |
M3700 | PF8380 | Pf-8380 is a potent autotaxin inhibitor with IC50 of 2.8 nM and 101 nM in in vitro enzyme assay and human whole blood cell assay, respectively. |
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