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Ro 20-1724

Cat. No. M20847
Ro 20-1724 Structure
Size Price Availability Quantity
5mg USD 48  USD48 In stock
10mg USD 76  USD76 In stock
25mg USD 155  USD155 In stock
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Quality Control & Documentation
Biological Activity

Ro 20-1724 is a potent inhibitor of PDE IV with Ki value of 3.1 μM and a potent gastric secretagogues.

Chemical Information
Molecular Weight 278.35
Formula C15H22N2O3
CAS Number 29925-17-5
Solubility (25°C) DMSO 56 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] S Peng, et al. J Neurosurg Sci. The phosphodiesterase-4 inhibitor Ro 20-1724 reverses learning and memory impairments, and downregulation of CREB in the hippocampus and cortex induced by ketamine anesthesia in immature rats

[2] Vivek Sharma, et al. Pharmacol Biochem Behav. Neuroprotective effect of RO-20-1724-a phosphodiesterase4 inhibitor against intracerebroventricular streptozotocin induced cognitive deficit and oxidative stress in rats

[3] F Petk, et al. J Appl Physiol (1985). Effects of salbutamol and Ro-20-1724 on airway and parenchymal mechanics in rats

[4] C M Lourenco, et al. Synapse. Imaging of cAMP-specific phosphodiesterase-IV: comparison of [11C]rolipram and [11C]Ro 20-1724 in rats

[5] M A Stawiski, et al. J Invest Dermatol. Ro 20-1724: an agent that significantly improves psoriatic lesions in double-blind clinical trials

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Keywords: Ro 20-1724 supplier, PDE, inhibitors, activators

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